About Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPSS2) is a protein
from Homo sapiens identified by UniProt accession
O95340, 614 residues long.
MolForge cross-references it against 0 known binders and
157 disease associations.
Target properties
| Protein name | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 |
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| UniProt accession | O95340 |
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| Gene | PAPSS2 |
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| Organism | Homo sapiens |
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| Length | 614 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (157)
Diseases linked to this target (Open Targets).
- spondyloepimetaphyseal dysplasia, PAPSS2 type · score 0.80
- Spondyloepimetaphyseal dysplasia, Pakistani type · score 0.72
- heel bone mineral density · score 0.48
- Spondyloepiphyseal dysplasia and spondyloepimetaphyseal dysplasia · score 0.46
- autosomal recessive brachyolmia · score 0.45
- bone quantitative ultrasound measurement · score 0.37
- serum metabolite measurement · score 0.31
- brachyolmia · score 0.27
- genetic disorder · score 0.19
- sigmoid neoplasm · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95340-F1 | alphafold | PREDICTED | 92.20 | — |
Amino-acid sequence (614 residues)
MSGIKKQKTE NQQKSTNVVY QAHHVSRNKR GQVVGTRGGF RGCTVWLTGL SGAGKTTISF ALEEYLVSHA IPCYSLDGDN VRHGLNRNLG FSPGDREENI RRIAEVAKLF ADAGLVCITS FISPFAKDRE NARKIHESAG LPFFEIFVDA PLNICESRDV KGLYKRARAG EIKGFTGIDS DYEKPETPER VLKTNLSTVS DCVHQVVELL QEQNIVPYTI IKDIHELFVP ENKLDHVRAE AETLPSLSIT KLDLQWVQVL SEGWATPLKG FMREKEYLQV MHFDTLLDDG VINMSIPIVL PVSAEDKTRL EGCSKFVLAH GGRRVAILRD AEFYEHRKEE RCSRVWGTTC TKHPHIKMVM ESGDWLVGGD LQVLEKIRWN DGLDQYRLTP LELKQKCKEM NADAVFAFQL RNPVHNGHAL LMQDTRRRLL ERGYKHPVLL LHPLGGWTKD DDVPLDWRMK QHAAVLEEGV LDPKSTIVAI FPSPMLYAGP TEVQWHCRSR MIAGANFYIV GRDPAGMPHP ETKKDLYEPT HGGKVLSMAP GLTSVEIIPF RVAAYNKAKK AMDFYDPARH NEFDFISGTR MRKLAREGEN PPDGFMAPKA WKVLTDYYRS LEKN
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