Homeobox protein SIX3 (SIX3)

About Homeobox protein SIX3

Homeobox protein SIX3 (SIX3) is a protein from Homo sapiens identified by UniProt accession O95343, 332 residues long. MolForge cross-references it against 0 known binders and 161 disease associations.

Target properties

Protein name	Homeobox protein SIX3
UniProt accession	O95343
Gene	SIX3
Organism	Homo sapiens
Length	332 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (161)

Diseases linked to this target (Open Targets).

holoprosencephaly · score 0.75
schizencephaly · score 0.65
alcohol consumption measurement · score 0.44
glucose measurement · score 0.43
diet measurement · score 0.43
smoking status measurement · score 0.43
alcohol use disorder measurement · score 0.43
HbA1c measurement · score 0.42
intraocular pressure measurement · score 0.41
smoking initiation · score 0.41

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95343-F1	alphafold	PREDICTED	67.85	—

Amino-acid sequence (332 residues)

MVFRSPLDLY SSHFLLPNFA DSHHRSILLA SSGGGNGAGG GGGAGGGSGG GNGAGGGGAG GAGGGGGGGS RAPPEELSMF QLPTLNFSPE QVASVCETLE ETGDIERLGR FLWSLPVAPG ACEAINKHES ILRARAVVAF HTGNFRDLYH ILENHKFTKE SHGKLQAMWL EAHYQEAEKL RGRPLGPVDK YRVRKKFPLP RTIWDGEQKT HCFKERTRSL LREWYLQDPY PNPSKKRELA QATGLTPTQV GNWFKNRRQR DRAAAAKNRL QHQAIGPSGM RSLAEPGCPT HGSAESPSTA ASPTTSVSSL TERADTGTSI LSVTSSDSEC DV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards