About Ubiquitin-like modifier-activating enzyme ATG7
Ubiquitin-like modifier-activating enzyme ATG7 (ATG7) is a protein
from Homo sapiens identified by UniProt accession
O95352, 703 residues long.
MolForge cross-references it against 0 known binders and
442 disease associations.
Target properties
| Protein name | Ubiquitin-like modifier-activating enzyme ATG7 |
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| UniProt accession | O95352 |
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| Gene | ATG7 |
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| Organism | Homo sapiens |
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| Length | 703 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (442)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.56
- cancer · score 0.55
- non-alcoholic fatty liver disease · score 0.44
- Global developmental delay · score 0.37
- Ataxia · score 0.37
- systolic blood pressure · score 0.34
- lysosomal storage disease · score 0.31
- pulse pressure measurement · score 0.30
- BMI-adjusted waist-hip ratio · score 0.30
- heel bone mineral density · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95352-F1 | alphafold | PREDICTED | 87.62 | — |
Amino-acid sequence (703 residues)
MAAATGDPGL SKLQFAPFSS ALDVGFWHEL TQKKLNEYRL DEAPKDIKGY YYNGDSAGLP ARLTLEFSAF DMSAPTPARC CPAIGTLYNT NTLESFKTAD KKLLLEQAAN EIWESIKSGT ALENPVLLNK FLLLTFADLK KYHFYYWFCY PALCLPESLP LIQGPVGLDQ RFSLKQIEAL ECAYDNLCQT EGVTALPYFL IKYDENMVLV SLLKHYSDFF QGQRTKITIG VYDPCNLAQY PGWPLRNFLV LAAHRWSSSF QSVEVVCFRD RTMQGARDVA HSIIFEVKLP EMAFSPDCPK AVGWEKNQKG GMGPRMVNLS ECMDPKRLAE SSVDLNLKLM CWRLVPTLDL DKVVSVKCLL LGAGTLGCNV ARTLMGWGVR HITFVDNAKI SYSNPVRQPL YEFEDCLGGG KPKALAAADR LQKIFPGVNA RGFNMSIPMP GHPVNFSSVT LEQARRDVEQ LEQLIESHDV VFLLMDTRES RWLPAVIAAS KRKLVINAAL GFDTFVVMRH GLKKPKQQGA GDLCPNHPVA SADLLGSSLF ANIPGYKLGC YFCNDVVAPG DSTRDRTLDQ QCTVSRPGLA VIAGALAVEL MVSVLQHPEG GYAIASSSDD RMNEPPTSLG LVPHQIRGFL SRFDNVLPVS LAFDKCTACS SKVLDQYERE GFNFLAKVFN SSHSFLEDLT GLTLLHQETQ AAEIWDMSDD ETI
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