About Tripartite motif-containing protein 16
Tripartite motif-containing protein 16 (TRIM16) is a protein
from Homo sapiens identified by UniProt accession
O95361, 564 residues long.
MolForge cross-references it against 0 known binders and
55 disease associations.
Target properties
| Protein name | Tripartite motif-containing protein 16 |
|---|
| UniProt accession | O95361 |
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| Gene | TRIM16 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 564 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (55)
Diseases linked to this target (Open Targets).
- melanoma · score 0.10
- neuroblastoma · score 0.09
- squamous cell carcinoma · score 0.09
- non-small cell lung carcinoma · score 0.08
- hepatocellular carcinoma · score 0.07
- neoplasm · score 0.07
- gonorrhea · score 0.06
- cancer · score 0.04
- Hemolytic anemia due to red cell pyruvate kinase deficiency · score 0.03
- IRIDA syndrome · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95361-F1 | alphafold | PREDICTED | 79.83 | — |
Amino-acid sequence (564 residues)
MAELDLMAPG PLPRATAQPP APLSPDSGSP SPDSGSASPV EEEDVGSSEK LGRETEEQDS DSAEQGDPAG EGKEVLCDFC LDDTRRVKAV KSCLTCMVNY CEEHLQPHQV NIKLQSHLLT EPVKDHNWRY CPAHHSPLSA FCCPDQQCIC QDCCQEHSGH TIVSLDAARR DKEAELQCTQ LDLERKLKLN ENAISRLQAN QKSVLVSVSE VKAVAEMQFG ELLAAVRKAQ ANVMLFLEEK EQAALSQANG IKAHLEYRSA EMEKSKQELE RMAAISNTVQ FLEEYCKFKN TEDITFPSVY VGLKDKLSGI RKVITESTVH LIQLLENYKK KLQEFSKEEE YDIRTQVSAV VQRKYWTSKP EPSTREQFLQ YAYDITFDPD TAHKYLRLQE ENRKVTNTTP WEHPYPDLPS RFLHWRQVLS QQSLYLHRYY FEVEIFGAGT YVGLTCKGID RKGEERNSCI SGNNFSWSLQ WNGKEFTAWY SDMETPLKAG PFRRLGVYID FPGGILSFYG VEYDTMTLVH KFACKFSEPV YAAFWLSKKE NAIRIVDLGE EPEKPAPSLV GTAP
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