About Phenylalanine--tRNA ligase, mitochondrial
Phenylalanine--tRNA ligase, mitochondrial (FARS2) is a protein
from Homo sapiens identified by UniProt accession
O95363, 451 residues long.
MolForge cross-references it against 0 known binders and
84 disease associations.
Target properties
| Protein name | Phenylalanine--tRNA ligase, mitochondrial |
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| UniProt accession | O95363 |
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| Gene | FARS2 |
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| Organism | Homo sapiens |
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| Length | 451 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (84)
Diseases linked to this target (Open Targets).
- combined oxidative phosphorylation defect type 14 · score 0.79
- hereditary spastic paraplegia 77 · score 0.75
- hereditary spastic paraplegia · score 0.53
- genetic disorder · score 0.50
- Congenital muscular dystrophy, Fukuyama type · score 0.34
- muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 4 · score 0.34
- lamellar ichthyosis · score 0.34
- Congenital muscular alpha-dystroglycanopathy with brain and eye anomalies · score 0.34
- body weight · score 0.34
- breast milk measurement · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95363-F1 | alphafold | PREDICTED | 89.64 | — |
Amino-acid sequence (451 residues)
MVGSALRRGA HAYVYLVSKA SHISRGHQHQ AWGSRPPAAE CATQRAPGSV VELLGKSYPQ DDHSNLTRKV LTRVGRNLHN QQHHPLWLIK ERVKEHFYKQ YVGRFGTPLF SVYDNLSPVV TTWQNFDSLL IPADHPSRKK GDNYYLNRTH MLRAHTSAHQ WDLLHAGLDA FLVVGDVYRR DQIDSQHYPI FHQLEAVRLF SKHELFAGIK DGESLQLFEQ SSRSAHKQET HTMEAVKLVE FDLKQTLTRL MAHLFGDELE IRWVDCYFPF THPSFEMEIN FHGEWLEVLG CGVMEQQLVN SAGAQDRIGW AFGLGLERLA MILYDIPDIR LFWCEDERFL KQFCVSNINQ KVKFQPLSKY PAVINDISFW LPSENYAEND FYDLVRTIGG DLVEKVDLID KFVHPKTHKT SHCYRITYRH MERTLSQREV RHIHQALQEA AVQLLGVEGR F
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