About E3 ubiquitin-protein ligase ARIH2
E3 ubiquitin-protein ligase ARIH2 (ARIH2) is a protein
from Homo sapiens identified by UniProt accession
O95376, 493 residues long.
MolForge cross-references it against 0 known binders and
123 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase ARIH2 |
|---|
| UniProt accession | O95376 |
|---|
| Gene | ARIH2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 493 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (123)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- autism spectrum disorder · score 0.26
- blood protein measurement · score 0.19
- platelet count · score 0.17
- self reported educational attainment · score 0.13
- heel bone mineral density · score 0.12
- depressive symptom measurement · score 0.11
- myoepithelial tumor · score 0.11
- reticulocyte count · score 0.10
- diastolic blood pressure · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95376-F1 | alphafold | PREDICTED | 86.48 | — |
Amino-acid sequence (493 residues)
MSVDMNSQGS DSNEEDYDPN CEEEEEEEED DPGDIEDYYV GVASDVEQQG ADAFDPEEYQ FTCLTYKESE GALNEHMTSL ASVLKVSHSV AKLILVNFHW QVSEILDRYK SNSAQLLVEA RVQPNPSKHV PTSHPPHHCA VCMQFVRKEN LLSLACQHQF CRSCWEQHCS VLVKDGVGVG VSCMAQDCPL RTPEDFVFPL LPNEELREKY RRYLFRDYVE SHYQLQLCPG ADCPMVIRVQ EPRARRVQCN RCNEVFCFKC RQMYHAPTDC ATIRKWLTKC ADDSETANYI SAHTKDCPKC NICIEKNGGC NHMQCSKCKH DFCWMCLGDW KTHGSEYYEC SRYKENPDIV NQSQQAQARE ALKKYLFYFE RWENHNKSLQ LEAQTYQRIH EKIQERVMNN LGTWIDWQYL QNAAKLLAKC RYTLQYTYPY AYYMESGPRK KLFEYQQAQL EAEIENLSWK VERADSYDRG DLENQMHIAE QRRRTLLKDF HDT
Explore E3 ubiquitin-protein ligase ARIH2 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets