About Gap junction beta-5 protein
Gap junction beta-5 protein (GJB5) is a protein
from Homo sapiens identified by UniProt accession
O95377, 273 residues long.
MolForge cross-references it against 0 known binders and
40 disease associations.
Target properties
| Protein name | Gap junction beta-5 protein |
|---|
| UniProt accession | O95377 |
|---|
| Gene | GJB5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 273 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (40)
Diseases linked to this target (Open Targets).
- daytime rest measurement · score 0.19
- hip bone size · score 0.17
- lung adenocarcinoma · score 0.14
- PHF-tau measurement · score 0.13
- non-small cell lung carcinoma · score 0.09
- viral load · score 0.08
- platelet component distribution width · score 0.07
- intraocular pressure measurement · score 0.06
- blood protein measurement · score 0.06
- neoplasm · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95377-F1 | alphafold | PREDICTED | 78.28 | — |
Amino-acid sequence (273 residues)
MNWSIFEGLL SGVNKYSTAF GRIWLSLVFI FRVLVYLVTA ERVWSDDHKD FDCNTRQPGC SNVCFDEFFP VSHVRLWALQ LILVTCPSLL VVMHVAYREV QEKRHREAHG ENSGRLYLNP GKKRGGLWWT YVCSLVFKAS VDIAFLYVFH SFYPKYILPP VVKCHADPCP NIVDCFISKP SEKNIFTLFM VATAAICILL NLVELIYLVS KRCHECLAAR KAQAMCTGHH PHGTTSSCKQ DDLLSGDLIF LGSDSHPPLL PDRPRDHVKK TIL
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