CCN family member 4 (CCN4)

About CCN family member 4

CCN family member 4 (CCN4) is a protein from Homo sapiens identified by UniProt accession O95388, 367 residues long. MolForge cross-references it against 0 known binders and 232 disease associations.

Target properties

Protein name	CCN family member 4
UniProt accession	O95388
Gene	CCN4
Organism	Homo sapiens
Length	367 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (232)

Diseases linked to this target (Open Targets).

hypothyroidism · score 0.39
diastolic blood pressure · score 0.37
blood protein measurement · score 0.36
diabetes mellitus · score 0.32
urate measurement · score 0.32
bone density · score 0.32
autoimmune disease · score 0.31
hyperthyroidism · score 0.31
autoimmune thyroid disease · score 0.31
Thyroid preparation use measurement · score 0.31

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95388-F1	alphafold	PREDICTED	77.17	—

Amino-acid sequence (367 residues)

MRWFLPWTLA AVTAAAASTV LATALSPAPT TMDFTPAPLE DTSSRPQFCK WPCECPPSPP RCPLGVSLIT DGCECCKMCA QQLGDNCTEA AICDPHRGLY CDYSGDRPRY AIGVCAQVVG VGCVLDGVRY NNGQSFQPNC KYNCTCIDGA VGCTPLCLRV RPPRLWCPHP RRVSIPGHCC EQWVCEDDAK RPRKTAPRDT GAFDAVGEVE AWHRNCIAYT SPWSPCSTSC GLGVSTRISN VNAQCWPEQE SRLCNLRPCD VDIHTLIKAG KKCLAVYQPE ASMNFTLAGC ISTRSYQPKY CGVCMDNRCC IPYKSKTIDV SFQCPDGLGF SRQVLWINAC FCNLSCRNPN DIFADLESYP DFSEIAN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards