Cellular communication network factor 6 (CCN6)

About Cellular communication network factor 6

Cellular communication network factor 6 (CCN6) is a protein from Homo sapiens identified by UniProt accession O95389, 354 residues long. MolForge cross-references it against 0 known binders and 85 disease associations.

Target properties

Protein name	Cellular communication network factor 6
UniProt accession	O95389
Gene	CCN6
Organism	Homo sapiens
Length	354 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (85)

Diseases linked to this target (Open Targets).

progressive pseudorheumatoid arthropathy of childhood · score 0.77
genetic disorder · score 0.47
Leigh syndrome · score 0.27
Metaphyseal chondrodysplasia, Schmid type · score 0.27
protein measurement · score 0.20
chondrosarcoma · score 0.10
hepatocellular carcinoma · score 0.08
non-small cell lung carcinoma · score 0.06
metabolite measurement · score 0.06
body height · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95389-F1	alphafold	PREDICTED	73.78	—

Amino-acid sequence (354 residues)

MQGLLFSTLL LAGLAQFCCR VQGTGPLDTT PEGRPGEVSD APQRKQFCHW PCKCPQQKPR CPPGVSLVRD GCGCCKICAK QPGEICNEAD LCDPHKGLYC DYSVDRPRYE TGVCAYLVAV GCEFNQVHYH NGQVFQPNPL FSCLCVSGAI GCTPLFIPKL AGSHCSGAKG GKKSDQSNCS LEPLLQQLST SYKTMPAYRN LPLIWKKKCL VQATKWTPCS RTCGMGISNR VTNENSNCEM RKEKRLCYIQ PCDSNILKTI KIPKGKTCQP TFQLSKAEKF VFSGCSSTQS YKPTFCGICL DKRCCIPNKS KMITIQFDCP NEGSFKWKML WITSCVCQRN CREPGDIFSE LKIL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards