About Growth/differentiation factor 11
Growth/differentiation factor 11 (GDF11) is a protein
from Homo sapiens identified by UniProt accession
O95390, 407 residues long.
MolForge cross-references it against 0 known binders and
304 disease associations.
Target properties
| Protein name | Growth/differentiation factor 11 |
|---|
| UniProt accession | O95390 |
|---|
| Gene | GDF11 |
|---|
| Organism | Homo sapiens |
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| Length | 407 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (304)
Diseases linked to this target (Open Targets).
- vertebral hypersegmentation and orofacial anomalies · score 0.62
- orofacial cleft · score 0.26
- Orofacial cleft · score 0.26
- neurodegenerative disease · score 0.24
- sitting height measurement · score 0.15
- cervical rib syndrome · score 0.10
- chronic obstructive pulmonary disease · score 0.10
- insulin resistance · score 0.09
- Spinal cord injury · score 0.08
- hepatocellular carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95390-F1 | alphafold | PREDICTED | 73.11 | — |
Amino-acid sequence (407 residues)
MVLAAPLLLG FLLLALELRP RGEAAEGPAA AAAAAAAAAA AGVGGERSSR PAPSVAPEPD GCPVCVWRQH SRELRLESIK SQILSKLRLK EAPNISREVV KQLLPKAPPL QQILDLHDFQ GDALQPEDFL EEDEYHATTE TVISMAQETD PAVQTDGSPL CCHFHFSPKV MFTKVLKAQL WVYLRPVPRP ATVYLQILRL KPLTGEGTAG GGGGGRRHIR IRSLKIELHS RSGHWQSIDF KQVLHSWFRQ PQSNWGIEIN AFDPSGTDLA VTSLGPGAEG LHPFMELRVL ENTKRSRRNL GLDCDEHSSE SRCCRYPLTV DFEAFGWDWI IAPKRYKANY CSGQCEYMFM QKYPHTHLVQ QANPRGSAGP CCTPTKMSPI NMLYFNDKQQ IIYGKIPGMV VDRCGCS
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