Bone morphogenetic protein 10 (BMP10)

About Bone morphogenetic protein 10

Bone morphogenetic protein 10 (BMP10) is a protein from Homo sapiens identified by UniProt accession O95393, 424 residues long. MolForge cross-references it against 0 known binders and 216 disease associations.

Target properties

Protein name	Bone morphogenetic protein 10
UniProt accession	O95393
Gene	BMP10
Organism	Homo sapiens
Length	424 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (216)

Diseases linked to this target (Open Targets).

hemoglobin measurement · score 0.30
hematocrit · score 0.29
colorectal neoplasm · score 0.26
gut microbiome measurement · score 0.22
lung adenocarcinoma · score 0.21
breast adenocarcinoma · score 0.18
endometrial cancer · score 0.14
atrial fibrillation · score 0.12
head and neck squamous cell carcinoma · score 0.11
monocyte count · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95393-F1	alphafold	PREDICTED	74.04	—

Amino-acid sequence (424 residues)

MGSLVLTLCA LFCLAAYLVS GSPIMNLEQS PLEEDMSLFG DVFSEQDGVD FNTLLQSMKD EFLKTLNLSD IPTQDSAKVD PPEYMLELYN KFATDRTSMP SANIIRSFKN EDLFSQPVSF NGLRKYPLLF NVSIPHHEEV IMAELRLYTL VQRDRMIYDG VDRKITIFEV LESKGDNEGE RNMLVLVSGE IYGTNSEWET FDVTDAIRRW QKSGSSTHQL EVHIESKHDE AEDASSGRLE IDTSAQNKHN PLLIVFSDDQ SSDKERKEEL NEMISHEQLP ELDNLGLDSF SSGPGEEALL QMRSNIIYDS TARIRRNAKG NYCKRTPLYI DFKEIGWDSW IIAPPGYEAY ECRGVCNYPL AEHLTPTKHA IIQALVHLKN SQKASKACCV PTKLEPISIL YLDKGVVTYK FKYEGMAVSE CGCR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards