Phosphoacetylglucosamine mutase (PGM3)

About Phosphoacetylglucosamine mutase

Phosphoacetylglucosamine mutase (PGM3) is a protein from Homo sapiens identified by UniProt accession O95394, 542 residues long. MolForge cross-references it against 0 known binders and 272 disease associations.

Target properties

Protein name	Phosphoacetylglucosamine mutase
UniProt accession	O95394
Gene	PGM3
Organism	Homo sapiens
Length	542 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (272)

Diseases linked to this target (Open Targets).

immunodeficiency 23 · score 0.84
severe combined immunodeficiency · score 0.46
Combined immunodeficiency · score 0.46
combined immunodeficiency · score 0.46
hyper-IgE syndrome · score 0.46
genetic disorder · score 0.41
Intellectual disability · score 0.37
pancreatic adenocarcinoma · score 0.21
brain measurement · score 0.09
bipolar disorder · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95394-F1	alphafold	PREDICTED	95.49	—

Amino-acid sequence (542 residues)

MDLGAITKYS ALHAKPNGLI LQYGTAGFRT KAEHLDHVMF RMGLLAVLRS KQTKSTIGVM VTASHNPEED NGVKLVDPLG EMLAPSWEEH ATCLANAEEQ DMQRVLIDIS EKEAVNLQQD AFVVIGRDTR PSSEKLSQSV IDGVTVLGGQ FHDYGLLTTP QLHYMVYCRN TGGRYGKATI EGYYQKLSKA FVELTKQASC SGDEYRSLKV DCANGIGALK LREMEHYFSQ GLSVQLFNDG SKGKLNHLCG ADFVKSHQKP PQGMEIKSNE RCCSFDGDAD RIVYYYHDAD GHFHLIDGDK IATLISSFLK ELLVEIGESL NIGVVQTAYA NGSSTRYLEE VMKVPVYCTK TGVKHLHHKA QEFDIGVYFE ANGHGTALFS TAVEMKIKQS AEQLEDKKRK AAKMLENIID LFNQAAGDAI SDMLVIEAIL ALKGLTVQQW DALYTDLPNR QLKVQVADRR VISTTDAERQ AVTPPGLQEA INDLVKKYKL SRAFVRPSGT EDVVRVYAEA DSQESADHLA HEVSLAVFQL AGGIGERPQP GF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards