About Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (GCNT3) is a protein
from Homo sapiens identified by UniProt accession
O95395, 438 residues long.
MolForge cross-references it against 0 known binders and
120 disease associations.
Target properties
| Protein name | Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 |
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| UniProt accession | O95395 |
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| Gene | GCNT3 |
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| Organism | Homo sapiens |
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| Length | 438 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (120)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.33
- sex hormone-binding globulin measurement · score 0.23
- glioblastoma multiforme · score 0.13
- taxonomic microbiome measurement · score 0.08
- gut microbiome measurement · score 0.08
- lymphocyte percentage of leukocytes · score 0.08
- neutrophil percentage of leukocytes · score 0.07
- macula measurement · score 0.07
- isolated agammaglobulinemia · score 0.06
- polymyalgia rheumatica · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95395-F1 | alphafold | PREDICTED | 94.06 | — |
Amino-acid sequence (438 residues)
MVQWKRLCQL HYLWALGCYM LLATVALKLS FRLKCDSDHL GLESRESQSQ YCRNILYNFL KLPAKRSINC SGVTRGDQEA VLQAILNNLE VKKKREPFTD THYLSLTRDC EHFKAERKFI QFPLSKEEVE FPIAYSMVIH EKIENFERLL RAVYAPQNIY CVHVDEKSPE TFKEAVKAII SCFPNVFIAS KLVRVVYASW SRVQADLNCM EDLLQSSVPW KYFLNTCGTD FPIKSNAEMV QALKMLNGRN SMESEVPPKH KETRWKYHFE VVRDTLHLTN KKKDPPPYNL TMFTGNAYIV ASRDFVQHVL KNPKSQQLIE WVKDTYSPDE HLWATLQRAR WMPGSVPNHP KYDISDMTSI ARLVKWQGHE GDIDKGAPYA PCSGIHQRAI CVYGAGDLNW MLQNHHLLAN KFDPKVDDNA LQCLEEYLRY KAIYGTEL
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