About Mediator of RNA polymerase II transcription subunit 26
Mediator of RNA polymerase II transcription subunit 26 (MED26) is a protein
from Homo sapiens identified by UniProt accession
O95402, 600 residues long.
MolForge cross-references it against 0 known binders and
21 disease associations.
Target properties
| Protein name | Mediator of RNA polymerase II transcription subunit 26 |
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| UniProt accession | O95402 |
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| Gene | MED26 |
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| Organism | Homo sapiens |
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| Length | 600 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (21)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- bone measurement · score 0.34
- self reported educational attainment · score 0.27
- intelligence · score 0.22
- schizophrenia · score 0.22
- bone mineral content measurement · score 0.21
- bone density · score 0.17
- lymphocyte count · score 0.10
- visual perception measurement · score 0.05
- neutrophil-to-lymphocyte ratio · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95402-F1 | alphafold | PREDICTED | 58.03 | — |
Amino-acid sequence (600 residues)
MTAAPASPQQ IRDRLLQAID PQSNIRNMVA VLEVISSLEK YPITKEALEE TRLGKLINDV RKKTKNEELA KRAKKLLRSW QKLIEPAHQH EAALRGLAGA TGSANGGAHN CRPEVGAAGP PRSIHDLKSR NDLQRLPGQR LDRLGSRKRR GDQRDLGHPG PPPKVSKASH DPLVPNSSPL PTNGISGSPE SFASSLDGSG HAGPEGSRLE RDENDKHSGK IPVNAVRPHT SSPGLGKPPG PCLQPKASVL QQLDRVDETP GPPHPKGPPR CSFSPRNSRH EGSFARQQSL YAPKGSVPSP SPRPQALDAT QVPSPLPLAQ PSTPPVRRLE LLPSAESPVC WLEQPESHQR LAGPGCKAGL SPAEPLLSRA GFSPDSSKAD SDAASSGGSD SKKKKRYRPR DYTVNLDGQV AEAGVKPVRL KERKLTFDPM TRQIKPLTQK EPVRADSPVH MEQQSRTELD KQEAKASLQS PFEQTNWKEL SRNEIIQSYL SRQSSLLSSS GAQTPGAHHF MSEYLKQEES TRQGARQLHV LVPQSPPTDL PGLTREVTQD DLDRIQASQW PGVNGCQDTQ GNWYDWTQCI SLDPHGDDGR LNILPYVCLD
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