About GPI ethanolamine phosphate transferase 1
GPI ethanolamine phosphate transferase 1 (PIGN) is a protein
from Homo sapiens identified by UniProt accession
O95427, 931 residues long.
MolForge cross-references it against 0 known binders and
77 disease associations.
Target properties
| Protein name | GPI ethanolamine phosphate transferase 1 |
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| UniProt accession | O95427 |
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| Gene | PIGN |
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| Organism | Homo sapiens |
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| Length | 931 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (77)
Diseases linked to this target (Open Targets).
- multiple congenital anomalies-hypotonia-seizures syndrome 1 · score 0.80
- multiple congenital anomalies-hypotonia-seizures syndrome · score 0.62
- genetic disorder · score 0.52
- Fryns syndrome · score 0.37
- Multiple congenital anomalies - hypotonia - seizures syndrome · score 0.37
- Abnormal brain morphology · score 0.27
- Seizure · score 0.12
- Intellectual disability · score 0.12
- Neurodevelopmental delay · score 0.12
- metabolite measurement · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95427-F1 | alphafold | PREDICTED | 88.18 | — |
Amino-acid sequence (931 residues)
MLLFFTLGLL IHFVFFASIF DIYFTSPLVH GMTPQFTPLP PPARRLVLFV ADGLRADALY ELDENGNSRA PFIRNIIMHE GSWGISHTRV PTESRPGHVA LIAGFYEDVS AVAKGWKENP VEFDSLFNES KYTWSWGSPD ILPMFAKGAS GDHVYTYSYD AKREDFGAQD ATKLDTWVFD NVKDFFHHAR NNQSLFSKIN EEKIVFFLHL LGIDTNGHAH RPSSRDYKHN IKKVDDGVKE IVSMFNHFYG NDGKTTFIFT SDHGMTDWGS HGAGHPSETL TPLVTWGAGI KYPQRVSAQQ FDDAFLKEWR LENWKRLDVN QADIAPLMTS LIGVPFPLNS VGILPVDYLN NTDLFKAESM FTNAVQILEQ FKVKMTQKKE VTLPFLFTPF KLLSDSKQFN ILRKARSYIK HRKFDEVVSL CKELIHLALK GLSYYHTYDR FFLGVNVVIG FVGWISYASL LIIKSHSNLI KGVSKEVKKP SHLLPCSFVA IGILVAFFLL IQACPWTYYV YGLLPLPIWY AVLREFQVIQ DLVVSVLTYP LSHFVGYLLA FTLGIEVLVL SFFYRYMLTA GLTAFAAWPF LTRLWTRAKM TSLSWTFFSL LLAVFPLMPV VGRKPDISLV MGAGLLVLLL SLCVVTSLMK RKDSFIKEEL LVHLLQVLST VLSMYVVYST QSSLLRKQGL PLMNQIISWA TLASSLVVPL LSSPVLFQRL FSILLSLMST YLLLSTGYEA LFPLVLSCLM FVWINIEQET LQQSGVCCKQ KLTSIQFSYN TDITQFRQLY LDDIRRAFFL VFFLVTAFFG TGNIASINSF DLASVYCFLT VFSPFMMGAL MMWKILIPFV LVMCAFEAVQ LTTQLSSKSL FLIVLVISDI MALHFFFLVK DYGSWLDIGT SISHYVIVMS MTIFLVFLNG LAQLLTTKKL RLCGKPKSHF M
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