Activator of 90 kDa heat shock protein ATPase…

About Activator of 90 kDa heat shock protein ATPase homolog 1

Activator of 90 kDa heat shock protein ATPase homolog 1 (AHSA1) is a protein from Homo sapiens identified by UniProt accession O95433, 338 residues long. MolForge cross-references it against 0 known binders and 59 disease associations.

Target properties

Protein name	Activator of 90 kDa heat shock protein ATPase homolog 1
UniProt accession	O95433
Gene	AHSA1
Organism	Homo sapiens
Length	338 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (59)

Diseases linked to this target (Open Targets).

leukocyte count · score 0.15
lymphocyte percentage of leukocytes · score 0.12
apolipoprotein A 1 measurement · score 0.11
hepatocellular carcinoma · score 0.10
neoplasm · score 0.09
eosinophil count · score 0.09
Miyoshi myopathy · score 0.08
retinitis pigmentosa · score 0.07
neutrophil percentage of leukocytes · score 0.06
myeloid white cell count · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95433-F1	alphafold	PREDICTED	80.75	—

Amino-acid sequence (338 residues)

MAKWGEGDPR WIVEERADAT NVNNWHWTER DASNWSTDKL KTLFLAVQVQ NEEGKCEVTE VSKLDGEASI NNRKGKLIFF YEWSVKLNWT GTSKSGVQYK GHVEIPNLSD ENSVDEVEIS VSLAKDEPDT NLVALMKEEG VKLLREAMGI YISTLKTEFT QGMILPTMNG ESVDPVGQPA LKTEERKAKP APSKTQARPV GVKIPTCKIT LKETFLTSPE ELYRVFTTQE LVQAFTHAPA TLEADRGGKF HMVDGNVSGE FTDLVPEKHI VMKWRFKSWP EGHFATITLT FIDKNGETEL CMEGRGIPAP EEERTRQGWQ RYYFEGIKQT FGYGARLF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Activator of 90 kDa heat shock protein ATPase homolog 1 (AHSA1)