About Poly(A)-specific ribonuclease PARN
Poly(A)-specific ribonuclease PARN (PARN) is a protein
from Homo sapiens identified by UniProt accession
O95453, 639 residues long.
MolForge cross-references it against 0 known binders and
94 disease associations.
Target properties
| Protein name | Poly(A)-specific ribonuclease PARN |
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| UniProt accession | O95453 |
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| Gene | PARN |
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| Organism | Homo sapiens |
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| Length | 639 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (94)
Diseases linked to this target (Open Targets).
- dyskeratosis congenita · score 0.78
- pulmonary fibrosis · score 0.58
- telomere length · score 0.58
- idiopathic pulmonary fibrosis · score 0.57
- pulmonary fibrosis and/or bone marrow failure, telomere-related, 1 · score 0.55
- telomere syndrome · score 0.42
- Hoyeraal-Hreidarsson syndrome · score 0.37
- mean corpuscular hemoglobin · score 0.37
- interstitial lung disease · score 0.26
- mean corpuscular volume · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95453-F1 | alphafold | PREDICTED | 81.04 | — |
Amino-acid sequence (639 residues)
MEIIRSNFKS NLHKVYQAIE EADFFAIDGE FSGISDGPSV SALTNGFDTP EERYQKLKKH SMDFLLFQFG LCTFKYDYTD SKYITKSFNF YVFPKPFNRS SPDVKFVCQS SSIDFLASQG FDFNKVFRNG IPYLNQEEER QLREQYDEKR SQANGAGALS YVSPNTSKCP VTIPEDQKKF IDQVVEKIED LLQSEENKNL DLEPCTGFQR KLIYQTLSWK YPKGIHVETL ETEKKERYIV ISKVDEEERK RREQQKHAKE QEELNDAVGF SRVIHAIANS GKLVIGHNML LDVMHTVHQF YCPLPADLSE FKEMTTCVFP RLLDTKLMAS TQPFKDIINN TSLAELEKRL KETPFNPPKV ESAEGFPSYD TASEQLHEAG YDAYITGLCF ISMANYLGSF LSPPKIHVSA RSKLIEPFFN KLFLMRVMDI PYLNLEGPDL QPKRDHVLHV TFPKEWKTSD LYQLFSAFGN IQISWIDDTS AFVSLSQPEQ VKIAVNTSKY AESYRIQTYA EYMGRKQEEK QIKRKWTEDS WKEADSKRLN PQCIPYTLQN HYYRNNSFTA PSTVGKRNLS PSQEEAGLED GVSGEISDTE LEQTDSCAEP LSEGRKKAKK LKRMKKELSP AGSISKNSPA TLFEVPDTW
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