UDP-D-glucose 4,6-dehydratase (TGDS)

About UDP-D-glucose 4,6-dehydratase

UDP-D-glucose 4,6-dehydratase (TGDS) is a protein from Homo sapiens identified by UniProt accession O95455, 350 residues long. MolForge cross-references it against 0 known binders and 71 disease associations.

Target properties

Protein name	UDP-D-glucose 4,6-dehydratase
UniProt accession	O95455
Gene	TGDS
Organism	Homo sapiens
Length	350 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (71)

Diseases linked to this target (Open Targets).

Catel-Manzke syndrome · score 0.80
alkaline phosphatase measurement · score 0.45
neurodegenerative disease · score 0.45
sex hormone-binding globulin measurement · score 0.44
triglyceride measurement · score 0.41
genetic disorder · score 0.41
Cleft palate · score 0.39
cleft palate · score 0.37
hair color · score 0.36
PHF-tau measurement · score 0.31

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95455-F1	alphafold	PREDICTED	94.28	—

Amino-acid sequence (350 residues)

MSAACWEEPW GLPGGFAKRV LVTGGAGFIA SHMIVSLVED YPNYMIINLD KLDYCASLKN LETISNKQNY KFIQGDICDS HFVKLLFETE KIDIVLHFAA QTHVDLSFVR AFEFTYVNVY GTHVLVSAAH EARVEKFIYV STDEVYGGSL DKEFDESSPK QPTNPYASSK AAAECFVQSY WEQYKFPVVI TRSSNVYGPH QYPEKVIPKF ISLLQHNRKC CIHGSGLQTR NFLYATDVVE AFLTVLKKGK PGEIYNIGTN FEMSVVQLAK ELIQLIKETN SESEMENWVD YVNDRPTNDM RYPMKSEKIH GLGWRPKVPW KEGIKKTIEW YRENFHNWKN VEKALEPFPV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards