Proteasome assembly chaperone 1 (PSMG1)

About Proteasome assembly chaperone 1

Proteasome assembly chaperone 1 (PSMG1) is a protein from Homo sapiens identified by UniProt accession O95456, 288 residues long. MolForge cross-references it against 0 known binders and 150 disease associations.

Target properties

Protein name	Proteasome assembly chaperone 1
UniProt accession	O95456
Gene	PSMG1
Organism	Homo sapiens
Length	288 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (150)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.54
ulcerative colitis · score 0.27
neutrophil count · score 0.26
inflammatory bowel disease · score 0.26
hemoglobin measurement · score 0.26
C-reactive protein measurement · score 0.25
Red cell distribution width · score 0.25
ankylosing spondylitis · score 0.25
leukocyte count · score 0.24
mean corpuscular hemoglobin concentration · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95456-F1	alphafold	PREDICTED	81.73	—

Amino-acid sequence (288 residues)

MAATFFGEVV KAPCRAGTED EEEEEEGRRE TPEDREVRLQ LARKREVRLL RRQTKTSLEV SLLEKYPCSK FIIAIGNNAV AFLSSFVMNS GVWEEVGCAK LWNEWCRTTD TTHLSSTEAF CVFYHLKSNP SVFLCQCSCY VAEDQQYQWL EKVFGSCPRK NMQITILTCR HVTDYKTSES TGSLPSPFLR ALKTQNFKDS ACCPLLEQPN IVHDLPAAVL SYCQVWKIPA ILYLCYTDVM KLDLITVEAF KPILSTRSLK GLVKNIPQST EILKKLMTTN EIQSNIYT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards