About Xylosyl- and glucuronyltransferase LARGE1
Xylosyl- and glucuronyltransferase LARGE1 (LARGE1) is a protein
from Homo sapiens identified by UniProt accession
O95461, 756 residues long.
MolForge cross-references it against 0 known binders and
427 disease associations.
Target properties
| Protein name | Xylosyl- and glucuronyltransferase LARGE1 |
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| UniProt accession | O95461 |
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| Gene | LARGE1 |
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| Organism | Homo sapiens |
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| Length | 756 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (427)
Diseases linked to this target (Open Targets).
- muscular dystrophy-dystroglycanopathy type B6 · score 0.78
- muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A6 · score 0.77
- muscular dystrophy-dystroglycanopathy, type A · score 0.64
- self reported educational attainment · score 0.49
- muscle-eye-brain disease · score 0.46
- intelligence · score 0.40
- mathematical ability · score 0.39
- Intellectual disability · score 0.37
- muscular dystrophy-dystroglycanopathy · score 0.37
- congenital muscular dystrophy with intellectual disability · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95461-F1 | alphafold | PREDICTED | 85.48 | — |
Amino-acid sequence (756 residues)
MLGICRGRRK FLAASLSLLC IPAITWIYLF SGSFEDGKPV SLSPLESQAH SPRYTASSQR ERESLEVRMR EVEEENRALR RQLSLAQGRA PSHRRGNHSK TYSMEEGTGD SENLRAGIVA GNSSECGQQP VVEKCETIHV AIVCAGYNAS RDVVTLVKSV LFHRRNPLHF HLIADSIAEQ ILATLFQTWM VPAVRVDFYN ADELKSEVSW IPNKHYSGIY GLMKLVLTKT LPANLERVIV LDTDITFATD IAELWAVFHK FKGQQVLGLV ENQSDWYLGN LWKNHRPWPA LGRGYNTGVI LLLLDKLRKM KWEQMWRLTA ERELMGMLST SLADQDIFNA VIKQNPFLVY QLPCFWNVQL SDHTRSEQCY RDVSDLKVIH WNSPKKLRVK NKHVEFFRNL YLTFLEYDGN LLRRELFGCP SEADVNSENL QKQLSELDED DLCYEFRRER FTVHRTHLYF LHYEYEPAAD STDVTLVAQL SMDRLQMLEA ICKHWEGPIS LALYLSDAEA QQFLRYAQGS EVLMSRHNVG YHIVYKEGQF YPVNLLRNVA MKHISTPYMF LSDIDFLPMY GLYEYLRKSV IQLDLANTKK AMIVPAFETL RYRLSFPKSK AELLSMLDMG TLFTFRYHVW TKGHAPTNFA KWRTATTPYR VEWEADFEPY VVVRRDCPEY DRRFVGFGWN KVAHIMELDV QEYEFIVLPN AYMIHMPHAP SFDITKFRSN KQYRICLKTL KEEFQQDMSR RYGFAALKYL TAENNS
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