About Sphingosine-1-phosphate lyase 1
Sphingosine-1-phosphate lyase 1 (SGPL1) is a protein
from Homo sapiens identified by UniProt accession
O95470, 568 residues long.
MolForge cross-references it against 0 known binders and
494 disease associations.
Target properties
| Protein name | Sphingosine-1-phosphate lyase 1 |
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| UniProt accession | O95470 |
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| Gene | SGPL1 |
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| Organism | Homo sapiens |
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| Length | 568 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (494)
Diseases linked to this target (Open Targets).
- nephrotic syndrome · score 0.71
- Hyperphenylalaninemia · score 0.55
- pterin-4 alpha-carbinolamine dehydratase 1 deficiency · score 0.55
- Lymphopenia · score 0.47
- lymphopenia · score 0.47
- steroid-resistant nephrotic syndrome · score 0.46
- focal segmental glomerulosclerosis · score 0.46
- ichthyosis · score 0.37
- adrenocortical insufficiency · score 0.37
- hydrops fetalis · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95470-F1 | alphafold | PREDICTED | 92.09 | — |
Amino-acid sequence (568 residues)
MPSTDLLMLK AFEPYLEILE VYSTKAKNYV NGHCTKYEPW QLIAWSVVWT LLIVWGYEFV FQPESLWSRF KKKCFKLTRK MPIIGRKIQD KLNKTKDDIS KNMSFLKVDK EYVKALPSQG LSSSAVLEKL KEYSSMDAFW QEGRASGTVY SGEEKLTELL VKAYGDFAWS NPLHPDIFPG LRKIEAEIVR IACSLFNGGP DSCGCVTSGG TESILMACKA YRDLAFEKGI KTPEIVAPQS AHAAFNKAAS YFGMKIVRVP LTKMMEVDVR AMRRAISRNT AMLVCSTPQF PHGVIDPVPE VAKLAVKYKI PLHVDACLGG FLIVFMEKAG YPLEHPFDFR VKGVTSISAD THKYGYAPKG SSLVLYSDKK YRNYQFFVDT DWQGGIYASP TIAGSRPGGI SAACWAALMH FGENGYVEAT KQIIKTARFL KSELENIKGI FVFGNPQLSV IALGSRDFDI YRLSNLMTAK GWNLNQLQFP PSIHFCITLL HARKRVAIQF LKDIRESVTQ IMKNPKAKTT GMGAIYGMAQ TTVDRNMVAE LSSVFLDSLY STDTVTQGSQ MNGSPKPH
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