About Homeobox protein SIX6
Homeobox protein SIX6 (SIX6) is a protein
from Homo sapiens identified by UniProt accession
O95475, 246 residues long.
MolForge cross-references it against 0 known binders and
258 disease associations.
Target properties
| Protein name | Homeobox protein SIX6 |
|---|
| UniProt accession | O95475 |
|---|
| Gene | SIX6 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 246 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (258)
Diseases linked to this target (Open Targets).
- Microphthalmia - cataract · score 0.72
- eye measurement · score 0.58
- open-angle glaucoma · score 0.48
- body height · score 0.46
- glaucoma · score 0.43
- lean body mass · score 0.43
- Developmental cataract · score 0.43
- sclerocornea · score 0.43
- early-onset non-syndromic cataract · score 0.43
- neurodegenerative disease · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95475-F1 | alphafold | PREDICTED | 80.08 | — |
Amino-acid sequence (246 residues)
MFQLPILNFS PQQVAGVCET LEESGDVERL GRFLWSLPVA PAACEALNKN ESVLRARAIV AFHGGNYREL YHILENHKFT KESHAKLQAL WLEAHYQEAE KLRGRPLGPV DKYRVRKKFP LPRTIWDGEQ KTHCFKERTR HLLREWYLQD PYPNPSKKRE LAQATGLTPT QVGNWFKNRR QRDRAAAAKN RLQQQVLSQG SGRALRAEGD GTPEVLGVAT SPAASLSSKA ATSAISITSS DSECDI
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