Ribosome biogenesis protein NSA2 homolog (NSA2)

About Ribosome biogenesis protein NSA2 homolog

Ribosome biogenesis protein NSA2 homolog (NSA2) is a protein from Homo sapiens identified by UniProt accession O95478, 260 residues long. MolForge cross-references it against 0 known binders and 55 disease associations.

Target properties

Protein name	Ribosome biogenesis protein NSA2 homolog
UniProt accession	O95478
Gene	NSA2
Organism	Homo sapiens
Length	260 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (55)

Diseases linked to this target (Open Targets).

heel bone mineral density · score 0.07
glycoprotein storage disease · score 0.05
neuronal ceroid lipofuscinosis 1 · score 0.04
hemoglobin H disease · score 0.04
hemoglobin C-beta-thalassemia syndrome · score 0.04
combined immunodeficiency due to OX40 deficiency · score 0.04
familial isolated congenital asplenia · score 0.04
Hyperlipoproteinemia type 1 · score 0.04
dominant beta-thalassemia · score 0.04
Lipedema · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95478-F1	alphafold	PREDICTED	87.68	—

Amino-acid sequence (260 residues)

MPQNEYIELH RKRYGYRLDY HEKKRKKESR EAHERSKKAK KMIGLKAKLY HKQRHAEKIQ MKKTIKMHEK RNTKQKNDEK TPQGAVPAYL LDREGQSRAK VLSNMIKQKR KEKAGKWEVP LPKVRAQGET EVLKVIRTGK RKKKAWKRMV TKVCFVGDGF TRKPPKYERF IRPMGLRFKK AHVTHPELKA TFCLPILGVK KNPSSPLYTT LGVITKGTVI EVNVSELGLV TQGGKVIWGK YAQVTNNPEN DGCINAVLLV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards