About GDH/6PGL endoplasmic bifunctional protein
GDH/6PGL endoplasmic bifunctional protein (H6PD) is a protein
from Homo sapiens identified by UniProt accession
O95479, 791 residues long.
MolForge cross-references it against 0 known binders and
281 disease associations.
Target properties
| Protein name | GDH/6PGL endoplasmic bifunctional protein |
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| UniProt accession | O95479 |
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| Gene | H6PD |
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| Organism | Homo sapiens |
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| Length | 791 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (281)
Diseases linked to this target (Open Targets).
- Hyperandrogenism due to cortisone reductase deficiency · score 0.69
- blood protein measurement · score 0.40
- body height · score 0.34
- monocyte count · score 0.29
- neurodegenerative disease · score 0.29
- aspartate aminotransferase measurement · score 0.27
- heel bone mineral density · score 0.26
- anthropometric measurement · score 0.25
- monocyte percentage of leukocytes · score 0.25
- neuroinflammatory disorder · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95479-F1 | alphafold | PREDICTED | 90.58 | — |
Amino-acid sequence (791 residues)
MWNMLIVAMC LALLGCLQAQ ELQGHVSIIL LGATGDLAKK YLWQGLFQLY LDEAGRGHSF SFHGAALTAP KQGQELMAKA LESLSCPKDM APSHCAEHKD QFLQLSQYRQ LKTAEDYQAL NKDIEAQLQH AGLREAGRIF YFSVPPFAYE DIARNINSSC RPGPGAWLRV VLEKPFGHDH FSAQQLATEL GTFFQEEEMY RVDHYLGKQA VAQILPFRDQ NRKALDGLWN RHHVERVEII MKETVDAEGR TSFYEEYGVI RDVLQNHLTE VLTLVAMELP HNVSSAEAVL RHKLQVFQAL RGLQRGSAVV GQYQSYSEQV RRELQKPDSF HSLTPTFAAV LVHIDNLRWE GVPFILMSGK ALDERVGYAR ILFKNQACCV QSEKHWAAAQ SQCLPRQLVF HIGHGDLGSP AVLVSRNLFR PSLPSSWKEM EGPPGLRLFG SPLSDYYAYS PVRERDAHSV LLSHIFHGRK NFFITTENLL ASWNFWTPLL ESLAHKAPRL YPGGAENGRL LDFEFSSGRL FFSQQQPEQL VPGPGPAPMP SDFQVLRAKY RESPLVSAWS EELISKLAND IEATAVRAVR RFGQFHLALS GGSSPVALFQ QLATAHYGFP WAHTHLWLVD ERCVPLSDPE SNFQGLQAHL LQHVRIPYYN IHPMPVHLQQ RLCAEEDQGA QIYAREISAL VANSSFDLVL LGMGADGHTA SLFPQSPTGL DGEQLVVLTT SPSQPHRRMS LSLPLINRAK KVAVLVMGRM KREITTLVSR VGHEPKKWPI SGVLPHSGQL VWYMDYDAFL G
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