Pantetheine hydrolase VNN2 (VNN2)

About Pantetheine hydrolase VNN2

Pantetheine hydrolase VNN2 (VNN2) is a protein from Homo sapiens identified by UniProt accession O95498, 520 residues long. MolForge cross-references it against 0 known binders and 64 disease associations.

Target properties

Protein name	Pantetheine hydrolase VNN2
UniProt accession	O95498
Gene	VNN2
Organism	Homo sapiens
Length	520 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (64)

Diseases linked to this target (Open Targets).

vitamin B12 deficiency · score 0.21
inflammatory bowel disease · score 0.13
prostate cancer · score 0.11
prostate carcinoma · score 0.11
Familial prostate cancer · score 0.11
cortical surface area measurement · score 0.09
heel bone mineral density · score 0.09
electrocardiography · score 0.09
bone density · score 0.08
neoplasm · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95498-F1	alphafold	PREDICTED	91.69	—

Amino-acid sequence (520 residues)

MVTSSFPISV AVFALITLQV GTQDSFIAAV YEHAVILPNK TETPVSQEDA LNLMNENIDI LETAIKQAAE QGARIIVTPE DALYGWKFTR ETVFPYLEDI PDPQVNWIPC QDPHRFGHTP VQARLSCLAK DNSIYVLANL GDKKPCNSRD STCPPNGYFQ YNTNVVYNTE GKLVARYHKY HLYSEPQFNV PEKPELVTFN TAFGRFGIFT CFDIFFYDPG VTLVKDFHVD TILFPTAWMN VLPLLTAIEF HSAWAMGMGV NLLVANTHHV SLNMTGSGIY APNGPKVYHY DMKTELGKLL LSEVDSHPLS SLAYPTAVNW NAYATTIKPF PVQKNTFRGF ISRDGFNFTE LFENAGNLTV CQKELCCHLS YRMLQKEENE VYVLGAFTGL HGRRRREYWQ VCTLLKCKTT NLTTCGRPVE TASTRFEMFS LSGTFGTEYV FPEVLLTEIH LSPGKFEVLK DGRLVNKNGS SGPILTVSLF GRWYTKDSLY SSCGTSNSAI TYLLIFILLM IIALQNIVML

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards