About Claudin-14
Claudin-14 (CLDN14) is a protein
from Homo sapiens identified by UniProt accession
O95500, 239 residues long.
MolForge cross-references it against 0 known binders and
92 disease associations.
Target properties
| Protein name | Claudin-14 |
|---|
| UniProt accession | O95500 |
|---|
| Gene | CLDN14 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 239 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (92)
Diseases linked to this target (Open Targets).
- deafness · score 0.66
- hearing loss, autosomal recessive · score 0.63
- hemoglobin measurement · score 0.48
- heel bone mineral density · score 0.47
- hematocrit · score 0.47
- erythrocyte count · score 0.46
- urolithiasis · score 0.46
- bone density · score 0.45
- Hearing impairment · score 0.44
- vein of Galen aneurysm · score 0.44
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95500-F1 | alphafold | PREDICTED | 80.20 | — |
Amino-acid sequence (239 residues)
MASTAVQLLG FLLSFLGMVG TLITTILPHW RRTAHVGTNI LTAVSYLKGL WMECVWHSTG IYQCQIYRSL LALPQDLQAA RALMVISCLL SGIACACAVI GMKCTRCAKG TPAKTTFAIL GGTLFILAGL LCMVAVSWTT NDVVQNFYNP LLPSGMKFEI GQALYLGFIS SSLSLIGGTL LCLSCQDEAP YRPYQAPPRA TTTTANTAPA YQPPAAYKDN RAPSVTSATH SGYRLNDYV
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