Chromobox protein homolog 6 (CBX6)

About Chromobox protein homolog 6

Chromobox protein homolog 6 (CBX6) is a protein from Homo sapiens identified by UniProt accession O95503, 412 residues long. MolForge cross-references it against 0 known binders and 65 disease associations.

Target properties

Protein name	Chromobox protein homolog 6
UniProt accession	O95503
Gene	CBX6
Organism	Homo sapiens
Length	412 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (65)

Diseases linked to this target (Open Targets).

body height · score 0.34
platelet count · score 0.31
blood protein measurement · score 0.26
platelet crit · score 0.24
lung adenocarcinoma · score 0.19
head and neck squamous cell carcinoma · score 0.19
endometrial cancer · score 0.18
self reported educational attainment · score 0.16
gastric adenocarcinoma · score 0.12
breast cancer · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95503-F1	alphafold	PREDICTED	60.66	—

Amino-acid sequence (412 residues)

MELSAVGERV FAAESIIKRR IRKGRIEYLV KWKGWAIKYS TWEPEENILD SRLIAAFEQK ERERELYGPK KRGPKPKTFL LKARAQAEAL RISDVHFSVK PSASASSPKL HSSAAVHRLK KDIRRCHRMS RRPLPRPDPQ GGSPGLRPPI SPFSETVRII NRKVKPREPK RNRIILNLKV IDKGAGGGGA GQGAGALARP KVPSRNRVIG KSKKFSESVL RTQIRHMKFG AFALYKPPPA PLVAPSPGKA EASAPGPGLL LAAPAAPYDA RSSGSSGCPS PTPQSSDPDD TPPKLLPETV SPSAPSWREP EVLDLSLPPE SAATSKRAPP EVTAAAGPAP PTAPEPAGAS SEPEAGDWRP EMSPCSNVVV TDVTSNLLTV TIKEFCNPED FEKVAAGVAG AAGGGGSIGA SK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards