PRAME family member 1 (PRAMEF1)

About PRAME family member 1

PRAME family member 1 (PRAMEF1) is a protein from Homo sapiens identified by UniProt accession O95521, 474 residues long. MolForge cross-references it against 0 known binders and 106 disease associations.

Target properties

Protein name	PRAME family member 1
UniProt accession	O95521
Gene	PRAMEF1
Organism	Homo sapiens
Length	474 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (106)

Diseases linked to this target (Open Targets).

azoospermia · score 0.09
partial chromosome Y deletion · score 0.08
spermatogenic failures 50 · score 0.08
spermatogenic failure, X-linked, 2 · score 0.08
spermatogenic failure 25 · score 0.08
spermatogenic failure 63 · score 0.07
isochromosomy Yp · score 0.07
male infertility with teratozoospermia due to single gene mutation · score 0.07
Male infertility with spermatogenesis disorder due to single gene mutation · score 0.07
spermatogenic failure 61 · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95521-F1	alphafold	PREDICTED	81.48	—

Amino-acid sequence (474 residues)

MSIQAPPRLL ELAGQSLLRD QALSISAMEE LPRVLYLPLF MEAFSRRHFQ TLTVMVQAWP FTCLPLGSLM KTLHLETLKA LLEGLHMLLT QKDRPRRWKL QVLDLRDVDE NFWARWPGAW ALSCFPETTS KRQTAEDCPR MGEHQPLKVF IDICLKEIPQ DECLRYLFQW VYQRRGLVHL CCSKLVNYLT PIKYLRKSLK IIYLNSIQEL EIRNMSWPRL IRKLRCYLKE MKNLRKLVFS RCHHYTSDNE LEGRLVAKFS SVFLRLEHLQ LLKIKLITFF SGHLEQLIRC LQNPLENLEL TYGYLLEEDM KCLSQYPSLG YLKHLNLSYV LLFRISLEPL GALLEKIAAS LKTLILEGCQ IHYSQLSAIL PGLSRCSQLT TFYFGRNCMS IDALKDLLRH TSGLSKLSLE TYPAPEESLN SLVRVNWEIF TPLRAELMCT LREVRQPKRI FIGPTPCPSC GSSPSEELEL HLCC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards