About PRAME family member 12
PRAME family member 12 (PRAMEF12) is a protein
from Homo sapiens identified by UniProt accession
O95522, 483 residues long.
MolForge cross-references it against 0 known binders and
114 disease associations.
Target properties
| Protein name | PRAME family member 12 |
|---|
| UniProt accession | O95522 |
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| Gene | PRAMEF12 |
|---|
| Organism | Homo sapiens |
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| Length | 483 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (114)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.09
- partial chromosome Y deletion · score 0.08
- spermatogenic failures 50 · score 0.08
- spermatogenic failure, X-linked, 2 · score 0.08
- spermatogenic failure 25 · score 0.08
- spermatogenic failure 63 · score 0.07
- isochromosomy Yp · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- Male infertility with spermatogenesis disorder due to single gene mutation · score 0.07
- spermatogenic failure 61 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95522-F1 | alphafold | PREDICTED | 85.71 | — |
Amino-acid sequence (483 residues)
MSLQAPPRLL ELAEQSLLRD RALAIPTLEE LPRELFPPLF MEAFTRRCCE TLTTMVQAWP FTCLPLGSLM KSCNLEIFRA VLEGLDALLA QKVRPRRWKL QVLDLRNVDE NFWGIWSGAS ALSPEALSKR RTAGNCPRPG GQQPLMVILD LCFKNGTLDE CLTHFLEWGK QRKGLLHVCC KELQIFGIAI HRIIEVLNTV ELDCIQEVEV CCPWELSILI RFAPYLGQMR NLRKLVLFNI HVSACIPLDR KEQFVIQFTS QFLKLDYFQK LYMHSVSFLE GHLDQLLRCL QAPLETVVMT ECLLSESDLK HLSWCPSIRQ LKELDLRGIT LTHFSPEPLS VLLEQAEATL QTLDLEDCGI VDSQLSAILP ALSRCSQLST FSFCGNLISM AALENLLRHT VGLSKLSLEL YPAPLESYDA QGALCWGRFS QLGAELMKTL RDLRQPKIIV FSTVPCPRCG IRASYDLEPS HCLLNACCQG GFI
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