NAD kinase (NADK)

About NAD kinase

NAD kinase (NADK) is a protein from Homo sapiens identified by UniProt accession O95544, 446 residues long. MolForge cross-references it against 0 known binders and 71 disease associations.

Target properties

Protein name	NAD kinase
UniProt accession	O95544
Gene	NADK
Organism	Homo sapiens
Length	446 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (71)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.43
systolic blood pressure · score 0.19
neuroinflammatory disorder · score 0.19
alkaline phosphatase measurement · score 0.15
cardiovascular disease · score 0.11
creatinine measurement · score 0.11
body weight · score 0.11
body mass index · score 0.11
vital capacity · score 0.10
blood phosphate measurement · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95544-F1	alphafold	PREDICTED	80.39	—

Amino-acid sequence (446 residues)

MEMEQEKMTM NKELSPDAAA YCCSACHGDE TWSYNHPIRG RAKSRSLSAS PALGSTKEFR RTRSLHGPCP VTTFGPKACV LQNPQTIMHI QDPASQRLTW NKSPKSVLVI KKMRDASLLQ PFKELCTHLM EENMIVYVEK KVLEDPAIAS DESFGAVKKK FCTFREDYDD ISNQIDFIIC LGGDGTLLYA SSLFQGSVPP VMAFHLGSLG FLTPFSFENF QSQVTQVIEG NAAVVLRSRL KVRVVKELRG KKTAVHNGLG ENGSQAAGLD MDVGKQAMQY QVLNEVVIDR GPSSYLSNVD VYLDGHLITT VQGDGVIVST PTGSTAYAAA AGASMIHPNV PAIMITPICP HSLSFRPIVV PAGVELKIML SPEARNTAWV SFDGRKRQEI RHGDSISITT SCYPLPSICV RDPVSDWFES LAQCLHWNVR KKQAHFEEEE EEEEEG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards