About Tyrosyl-DNA phosphodiesterase 2
Tyrosyl-DNA phosphodiesterase 2 (TDP2) is a protein
from Homo sapiens identified by UniProt accession
O95551, 362 residues long.
MolForge cross-references it against 0 known binders and
84 disease associations.
Target properties
| Protein name | Tyrosyl-DNA phosphodiesterase 2 |
|---|
| UniProt accession | O95551 |
|---|
| Gene | TDP2 |
|---|
| Organism | Homo sapiens |
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| Length | 362 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (84)
Diseases linked to this target (Open Targets).
- spinocerebellar ataxia, autosomal recessive 23 · score 0.66
- Autosomal recessive cerebellar ataxia-epilepsy-intellectual disability syndrome due to TUD deficiency · score 0.65
- neurodegenerative disease · score 0.53
- alkaline phosphatase measurement · score 0.47
- genetic disorder · score 0.41
- cerebellar ataxia · score 0.34
- ovarian cancer · score 0.18
- glioblastoma multiforme · score 0.12
- lung adenocarcinoma · score 0.12
- clear cell renal carcinoma · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95551-F1 | alphafold | PREDICTED | 85.10 | — |
Amino-acid sequence (362 residues)
MELGSCLEGG REAAEEEGEP EVKKRRLLCV EFASVASCDA AVAQCFLAEN DWEMERALNS YFEPPVEESA LERRPETISE PKTYVDLTNE ETTDSTTSKI SPSEDTQQEN GSMFSLITWN IDGLDLNNLS ERARGVCSYL ALYSPDVIFL QEVIPPYYSY LKKRSSNYEI ITGHEEGYFT AIMLKKSRVK LKSQEIIPFP STKMMRNLLC VHVNVSGNEL CLMTSHLEST RGHAAERMNQ LKMVLKKMQE APESATVIFA GDTNLRDREV TRCGGLPNNI VDVWEFLGKP KHCQYTWDTQ MNSNLGITAA CKLRFDRIFF RAAAEEGHII PRSLDLLGLE KLDCGRFPSD HWGLLCNLDI IL
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