About Histidine protein methyltransferase 1 homolog
Histidine protein methyltransferase 1 homolog (METTL18) is a protein
from Homo sapiens identified by UniProt accession
O95568, 372 residues long.
MolForge cross-references it against 0 known binders and
20 disease associations.
Target properties
| Protein name | Histidine protein methyltransferase 1 homolog |
|---|
| UniProt accession | O95568 |
|---|
| Gene | METTL18 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 372 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (20)
Diseases linked to this target (Open Targets).
- leukocyte count · score 0.21
- monocyte count · score 0.15
- PHF-tau measurement · score 0.12
- hepatocellular carcinoma · score 0.08
- blood protein measurement · score 0.07
- body height · score 0.06
- e-selectin measurement · score 0.06
- age at menopause · score 0.05
- MODY · score 0.05
- neoplasm · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95568-F1 | alphafold | PREDICTED | 74.35 | — |
Amino-acid sequence (372 residues)
MTFQFNFTIE DHLENELTPI RDGALTLDSS KELSVSESQK GEERDRKCSA EQFDLPQDHL WEHKSMENAA PSQDTDSPLS AASSSRNLEP HGKQPSLRAA KEHAMPKDLK KMLENKVIET LPGFQHVKLS VVKTILLKEN FPGENIVSKS FSSHSDLITG VYEGGLKIWE CTFDLLAYFT KAKVKFAGKK VLDLGCGSGL LGITAFKGGS KEIHFQDYNS MVIDEVTLPN VVANSTLEDE ENDVNEPDVK RCRKPKVTQL YKCRFFSGEW SEFCKLVLSS EKLFVKYDLI LTSETIYNPD YYSNLHQTFL RLLSKNGRVL LASKAHYFGV GGGVHLFQKF VEERDVFKTR ILKIIDEGLK RFIIEITFKF PG
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