Persulfide dioxygenase ETHE1, mitochondrial (ETHE1)

About Persulfide dioxygenase ETHE1, mitochondrial

Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) is a protein from Homo sapiens identified by UniProt accession O95571, 254 residues long. MolForge cross-references it against 0 known binders and 78 disease associations.

Target properties

Protein name	Persulfide dioxygenase ETHE1, mitochondrial
UniProt accession	O95571
Gene	ETHE1
Organism	Homo sapiens
Length	254 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (78)

Diseases linked to this target (Open Targets).

ethylmalonic encephalopathy · score 0.84
Leigh syndrome · score 0.37
Abnormality of the nervous system · score 0.27
glutaryl-CoA dehydrogenase deficiency · score 0.27
genetic disorder · score 0.18
neurodegenerative disease · score 0.17
calcium measurement · score 0.16
body height · score 0.10
triple-negative breast cancer · score 0.07
thrombocytopenia 4 · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95571-F1	alphafold	PREDICTED	92.90	—

Amino-acid sequence (254 residues)

MAEAVLRVAR RQLSQRGGSG APILLRQMFE PVSCTFTYLL GDRESREAVL IDPVLETAPR DAQLIKELGL RLLYAVNTHC HADHITGSGL LRSLLPGCQS VISRLSGAQA DLHIEDGDSI RFGRFALETR ASPGHTPGCV TFVLNDHSMA FTGDALLIRG CGRTDFQQGC AKTLYHSVHE KIFTLPGDCL IYPAHDYHGF TVSTVEEERT LNPRLTLSCE EFVKIMGNLN LPKPQQIDFA VPANMRCGVQ TPTA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards