About Krueppel-like factor 8
Krueppel-like factor 8 (KLF8) is a protein
from Homo sapiens identified by UniProt accession
O95600, 359 residues long.
MolForge cross-references it against 0 known binders and
67 disease associations.
Target properties
| Protein name | Krueppel-like factor 8 |
|---|
| UniProt accession | O95600 |
|---|
| Gene | KLF8 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 359 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (67)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.27
- coronary artery disease · score 0.16
- hepatocellular carcinoma · score 0.11
- neoplasm · score 0.10
- urinary bladder carcinoma · score 0.08
- lung adenocarcinoma · score 0.08
- glioma · score 0.07
- triple-negative breast cancer · score 0.07
- gonorrhea · score 0.06
- breast cancer · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95600-F1 | alphafold | PREDICTED | 50.72 | — |
Amino-acid sequence (359 residues)
MVDMDKLINN LEVQLNSEGG SMQVFKQVTA SVRNRDPPEI EYRSNMTSPT LLDANPMENP ALFNDIKIEP PEELLASDFS LPQVEPVDLS FHKPKAPLQP ASMLQAPIRP PKPQSSPQTL VVSTSTSDMS TSANIPTVLT PGSVLTSSQS TGSQQILHVI HTIPSVSLPN KMGGLKTIPV VVQSLPMVYT TLPADGGPAA ITVPLIGGDG KNAGSVKVDP TSMSPLEIPS DSEESTIESG SSALQSLQGL QQEPAAMAQM QGEESLDLKR RRIHQCDFAG CSKVYTKSSH LKAHRRIHTG EKPYKCTWDG CSWKFARSDE LTRHFRKHTG IKPFRCTDCN RSFSRSDHLS LHRRRHDTM
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