tRNA-dihydrouridine(20a/20b) synthase…

About tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like

tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like (DUS4L) is a protein from Homo sapiens identified by UniProt accession O95620, 317 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.

Target properties

Protein name	tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like
UniProt accession	O95620
Gene	DUS4L
Organism	Homo sapiens
Length	317 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (30)

Diseases linked to this target (Open Targets).

COG5-congenital disorder of glycosylation · score 0.45
neurodegenerative disease · score 0.29
coronary artery disease · score 0.14
congenital disorder of glycosylation · score 0.12
alkaline phosphatase measurement · score 0.11
hemoglobin A1 measurement · score 0.07
low density lipoprotein cholesterol measurement · score 0.07
vitamin D measurement · score 0.07
electrocardiography · score 0.06
lung adenocarcinoma · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95620-F1	alphafold	PREDICTED	94.39	—

Amino-acid sequence (317 residues)

MKSDCMQTTI CQERKKDPIE MFHSGQLVKV CAPMVRYSKL AFRTLVRKYS CDLCYTPMIV AADFVKSIKA RDSEFTTNQG DCPLIVQFAA NDARLLSDAA RIVCPYANGI DINCGCPQRW AMAEGYGACL INKPELVQDM VKQVRNQVET PGFSVSIKIR IHDDLKRTVD LCQKAEATGV SWITVHGRTA EERHQPVHYD SIKIIKENMS IPVIANGDIR SLKEAENVWR ITGTDGVMVA RGLLANPAMF AGYEETPLKC IWDWVDIALE LGTPYMCFHQ HLMYMMEKIT SRQEKRVFNA LSSTSAIIDY LTDHYGI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like (DUS4L)