About Zinc finger and BTB domain-containing protein 11
Zinc finger and BTB domain-containing protein 11 (ZBTB11) is a protein
from Homo sapiens identified by UniProt accession
O95625, 1053 residues long.
MolForge cross-references it against 0 known binders and
39 disease associations.
Target properties
| Protein name | Zinc finger and BTB domain-containing protein 11 |
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| UniProt accession | O95625 |
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| Gene | ZBTB11 |
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| Organism | Homo sapiens |
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| Length | 1053 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (39)
Diseases linked to this target (Open Targets).
- autosomal recessive non-syndromic intellectual disability · score 0.57
- Intellectual disability · score 0.19
- COVID-19 · score 0.13
- body height · score 0.12
- reticulocyte count · score 0.09
- cancer · score 0.08
- neoplasm · score 0.08
- breast cancer · score 0.07
- Neoplasm of the lung · score 0.05
- sex hormone-binding globulin measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95625-F1 | alphafold | PREDICTED | 61.12 | — |
Amino-acid sequence (1053 residues)
MSSEESYRAI LRYLTNEREP YAPGTEGNVK RKIRKAAACY VVRGGTLYYQ RRQRHRKTFA ELEVVLQPER RRDLIEAAHL GPGGTHHTRH QTWHYLSKTY WWRGILKQVK DYIKQCSKCQ EKLDRSRPIS DVSEMLEELG LDLESGEESN ESEDDLSNFT SSPTTASKPA KKKPVSKHEL VFVDTKGVVK RSSPKHCQAV LKQLNEQRLS NQFCDVTLLI EGEEYKAHKS VLSANSEYFR DLFIEKGAVS SHEAVVDLSG FCKASFLPLL EFAYTSVLSF DFCSMADVAI LARHLFMSEV LEICESVHKL MEEKQLTVYK KGEVQTVAST QDLRVQNGGT APPVASSEGT TTSLPTELGD CEIVLLVNGE LPEAEQNGEV GRQPEPQVSS EAESALSSVG CIADSHPEME SVDLITKNNQ TELETSNNRE NNTVSNIHPK LSKENVISSS PEDSGMGNDI SAEDICAEDI PKHRQKVDQP LKDQENLVAS TAKTDFGPDD DTYRSRLRQR SVNEGAYIRL HKGMEKKLQK RKAVPKSAVQ QVAQKLVQRG KKMKQPKRDA KENTEEASHK CGECGMVFQR RYALIMHKLK HERARDYKCP LCKKQFQYSA SLRAHLIRHT RKDAPSSSSS NSTSNEASGT SSEKGRTKRE FICSICGRTL PKLYSLRIHM LKHTGVKPHA CQVCGKTFIY KHGLKLHQSL HQSQKQFQCE LCVKSFVTKR SLQEHMSIHT GESKYLCSVC GKSFHRGSGL SKHFKKHQPK PEVRGYHCTQ CEKSFFEARD LRQHMNKHLG VKPFQCQFCD KCYSWKKDWY SHVKSHSVTE PYRCNICGKE FYEKALFRRH VKKATHGKKG RAKQNLERVC EKCGRKFTQL REYRRHMNNH EGVKPFECLT CGVAWADARS LKRHVRTHTG ERPYVCPVCS EAYIDARTLR KHMTKFHRDY VPCKIMLEKD TLQFHNQGTQ VAHAVSILTA GMQEQESSGP QELETVVVTG ETMEALEAVA ATEEYPSVST LSDQSIMQVV NYVLAQQQGQ KLSEVAEAIQ TVKVEVAHIS GGE
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