About CCR4-NOT transcription complex subunit 4
CCR4-NOT transcription complex subunit 4 (CNOT4) is a protein
from Homo sapiens identified by UniProt accession
O95628, 575 residues long.
MolForge cross-references it against 0 known binders and
57 disease associations.
Target properties
| Protein name | CCR4-NOT transcription complex subunit 4 |
|---|
| UniProt accession | O95628 |
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| Gene | CNOT4 |
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| Organism | Homo sapiens |
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| Length | 575 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (57)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- body height · score 0.46
- sex hormone-binding globulin measurement · score 0.43
- appendicular lean mass · score 0.43
- self reported educational attainment · score 0.41
- lysosomal storage disease · score 0.37
- lean body mass · score 0.37
- serum gamma-glutamyl transferase measurement · score 0.36
- mathematical ability · score 0.36
- heel bone mineral density · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95628-F1 | alphafold | PREDICTED | 61.70 | — |
Amino-acid sequence (575 residues)
MSRSPDAKED PVECPLCMEP LEIDDINFFP CTCGYQICRF CWHRIRTDEN GLCPACRKPY PEDPAVYKPL SQEELQRIKN EKKQKQNERK QKISENRKHL ASVRVVQKNL VFVVGLSQRL ADPEVLKRPE YFGKFGKIHK VVINNSTSYA GSQGPSASAY VTYIRSEDAL RAIQCVNNVV VDGRTLKASL GTTKYCSYFL KNMQCPKPDC MYLHELGDEA ASFTKEEMQA GKHQEYEQKL LQELYKLNPN FLQLSTGSVD KNKNKVTPLQ RYDTPIDKPS DSLSIGNGDN SQQISNSDTP SPPPGLSKSN PVIPISSSNH SARSPFEGAV TESQSLFSDN FRHPNPIPSG LPPFPSSPQT SSDWPTAPEP QSLFTSETIP VSSSTDWQAA FGFGSSKQPE DDLGFDPFDV TRKALADLIE KELSVQDQPS LSPTSLQNSS SHTTTAKGPG SGFLHPAAAT NANSLNSTFS VLPQRFPQFQ QHRAVYNSFS FPGQAARYPW MAFPRNSIMH LNHTANPTSN SNFLDLNLPP QHNTGLGGIP VAGEEEVKVS TMPLSTSSHS LQQGQQPTSL HTTVA
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