About Netrin-1
Netrin-1 (NTN1) is a protein
from Homo sapiens identified by UniProt accession
O95631, 604 residues long.
MolForge cross-references it against 0 known binders and
419 disease associations.
Target properties
| Protein name | Netrin-1 |
|---|
| UniProt accession | O95631 |
|---|
| Gene | NTN1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 604 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (419)
Diseases linked to this target (Open Targets).
- mirror movements 4 · score 0.62
- cleft lip · score 0.51
- Cleft palate · score 0.49
- neuroticism measurement · score 0.48
- heel bone mineral density · score 0.47
- blood protein measurement · score 0.47
- Orofacial cleft · score 0.43
- familial congenital mirror movements · score 0.37
- white matter microstructure measurement · score 0.37
- bone quantitative ultrasound measurement · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95631-F1 | alphafold | PREDICTED | 88.49 | — |
Amino-acid sequence (604 residues)
MMRAVWEALA ALAAVACLVG AVRGGPGLSM FAGQAAQPDP CSDENGHPRR CIPDFVNAAF GKDVRVSSTC GRPPARYCVV SERGEERLRS CHLCNASDPK KAHPPAFLTD LNNPHNLTCW QSENYLQFPH NVTLTLSLGK KFEVTYVSLQ FCSPRPESMA IYKSMDYGRT WVPFQFYSTQ CRKMYNRPHR APITKQNEQE AVCTDSHTDM RPLSGGLIAF STLDGRPSAH DFDNSPVLQD WVTATDIRVA FSRLHTFGDE NEDDSELARD SYFYAVSDLQ VGGRCKCNGH AARCVRDRDD SLVCDCRHNT AGPECDRCKP FHYDRPWQRA TAREANECVA CNCNLHARRC RFNMELYKLS GRKSGGVCLN CRHNTAGRHC HYCKEGYYRD MGKPITHRKA CKACDCHPVG AAGKTCNQTT GQCPCKDGVT GITCNRCAKG YQQSRSPIAP CIKIPVAPPT TAASSVEEPE DCDSYCKASK GKLKINMKKY CKKDYAVQIH ILKADKAGDW WKFTVNIISV YKQGTSRIRR GDQSLWIRSR DIACKCPKIK PLKKYLLLGN AEDSPDQSGI VADKSSLVIQ WRDTWARRLR KFQQREKKGK CKKA
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