About Cleavage and polyadenylation specificity factor subunit 4
Cleavage and polyadenylation specificity factor subunit 4 (CPSF4) is a protein
from Homo sapiens identified by UniProt accession
O95639, 269 residues long.
MolForge cross-references it against 0 known binders and
166 disease associations.
Target properties
| Protein name | Cleavage and polyadenylation specificity factor subunit 4 |
|---|
| UniProt accession | O95639 |
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| Gene | CPSF4 |
|---|
| Organism | Homo sapiens |
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| Length | 269 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (166)
Diseases linked to this target (Open Targets).
- influenza · score 0.37
- clear cell renal carcinoma · score 0.25
- neurodegenerative disease · score 0.23
- reticulocyte count · score 0.14
- mean platelet volume · score 0.13
- HbA1c measurement · score 0.11
- leukocyte count · score 0.08
- body fat percentage · score 0.08
- fat body mass · score 0.07
- platelet count · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95639-F1 | alphafold | PREDICTED | 75.94 | — |
Amino-acid sequence (269 residues)
MQEIIASVDH IKFDLEIAVE QQLGAQPLPF PGMDKSGAAV CEFFLKAACG KGGMCPFRHI SGEKTVVCKH WLRGLCKKGD QCEFLHEYDM TKMPECYFYS KFGECSNKEC PFLHIDPESK IKDCPWYDRG FCKHGPLCRH RHTRRVICVN YLVGFCPEGP SCKFMHPRFE LPMGTTEQPP LPQQTQPPAK QSNNPPLQRS SSLIQLTSQN SSPNQQRTPQ VIGVMQSQNS SAGNRGPRPL EQVTCYKCGE KGHYANRCTK GHLAFLSGQ
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