About GTP-binding protein Di-Ras3
GTP-binding protein Di-Ras3 (DIRAS3) is a protein
from Homo sapiens identified by UniProt accession
O95661, 229 residues long.
MolForge cross-references it against 0 known binders and
107 disease associations.
Target properties
| Protein name | GTP-binding protein Di-Ras3 |
|---|
| UniProt accession | O95661 |
|---|
| Gene | DIRAS3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 229 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (107)
Diseases linked to this target (Open Targets).
- HMG CoA reductase inhibitor use measurement · score 0.25
- cortical thickness · score 0.14
- bone quantitative ultrasound measurement · score 0.14
- heel bone mineral density · score 0.13
- bone density · score 0.12
- cortical surface area measurement · score 0.11
- neuroimaging measurement · score 0.11
- brain measurement · score 0.10
- PHF-tau measurement · score 0.09
- non-small cell lung carcinoma · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95661-F1 | alphafold | PREDICTED | 73.15 | — |
Amino-acid sequence (229 residues)
MGNASFGSKE QKLLKRLRLL PALLILRAFK PHRKIRDYRV VVVGTAGVGK STLLHKWASG NFRHEYLPTI ENTYCQLLGC SHGVLSLHIT DSKSGDGNRA LQRHVIARGH AFVLVYSVTK KETLEELKAF YELICKIKGN NLHKFPIVLV GNKSDDTHRE VALNDGATCA MEWNCAFMEI SAKTDVNVQE LFHMLLNYKK KPTTGLQEPE KKSQMPNTTE KLLDKCIIM
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