About Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein
Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein (ASMTL) is a protein
from Homo sapiens identified by UniProt accession
O95671, 621 residues long.
MolForge cross-references it against 0 known binders and
35 disease associations.
Target properties
| Protein name | Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein |
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| UniProt accession | O95671 |
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| Gene | ASMTL |
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| Organism | Homo sapiens |
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| Length | 621 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (35)
Diseases linked to this target (Open Targets).
- hepatocellular carcinoma · score 0.09
- triple-negative breast cancer · score 0.05
- neoplasm · score 0.05
- lung adenocarcinoma · score 0.02
- osteosarcoma · score 0.02
- cancer · score 0.02
- renal cell carcinoma · score 0.01
- Alzheimer disease · score 0.01
- papillary thyroid carcinoma · score 0.01
- breast cancer · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95671-F1 | alphafold | PREDICTED | 87.33 | — |
Amino-acid sequence (621 residues)
MVLCPVIGKL LHKRVVLASA SPRRQEILSN AGLRFEVVPS KFKEKLDKAS FATPYGYAME TAKQKALEVA NRLYQKDLRA PDVVIGADTI VTVGGLILEK PVDKQDAYRM LSRLSGREHS VFTGVAIVHC SSKDHQLDTR VSEFYEETKV KFSELSEELL WEYVHSGEPM DKAGGYGIQA LGGMLVESVH GDFLNVVGFP LNHFCKQLVK LYYPPRPEDL RRSVKHDSIP AADTFEDLSD VEGGGSEPTQ RDAGSRDEKA EAGEAGQATA EAECHRTRET LPPFPTRLLE LIEGFMLSKG LLTACKLKVF DLLKDEAPQK AADIASKVDA SACGMERLLD ICAAMGLLEK TEQGYSNTET ANVYLASDGE YSLHGFIMHN NDLTWNLFTY LEFAIREGTN QHHRALGKKA EDLFQDAYYQ SPETRLRFMR AMHGMTKLTA CQVATAFNLS RFSSACDVGG CTGALARELA REYPRMQVTV FDLPDIIELA AHFQPPGPQA VQIHFAAGDF FRDPLPSAEL YVLCRILHDW PDDKVHKLLS RVAESCKPGA GLLLVETLLD EEKRVAQRAL MQSLNMLVQT EGKERSLGEY QCLLELHGFH QVQVVHLGGV LDAILATKVA P
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