About Protein phosphatase EYA4
Protein phosphatase EYA4 (EYA4) is a protein
from Homo sapiens identified by UniProt accession
O95677, 639 residues long.
MolForge cross-references it against 0 known binders and
214 disease associations.
Target properties
| Protein name | Protein phosphatase EYA4 |
|---|
| UniProt accession | O95677 |
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| Gene | EYA4 |
|---|
| Organism | Homo sapiens |
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| Length | 639 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (214)
Diseases linked to this target (Open Targets).
- dilated cardiomyopathy 1J · score 0.68
- autosomal dominant nonsyndromic hearing loss 10 · score 0.68
- deafness · score 0.67
- heel bone mineral density · score 0.54
- autosomal dominant nonsyndromic hearing loss · score 0.52
- bone quantitative ultrasound measurement · score 0.52
- Sensorineural deafness with dilated cardiomyopathy · score 0.51
- body height · score 0.48
- leukocyte count · score 0.48
- BMI-adjusted waist-hip ratio · score 0.46
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95677-F1 | alphafold | PREDICTED | 62.71 | — |
Amino-acid sequence (639 residues)
MEDSQDLNEQ SVKKTCTESD VSQSQNSRSM EMQDLASPHT LVGGGDTPGS SKLEKSNLSS TSVTTNGTGG ENMTVLNTAD WLLSCNTPSS ATMSLLAVKT EPLNSSETTA TTGDGALDTF TGSVITSSGY SPRSAHQYSP QLYPSKPYPH ILSTPAAQTM SAYAGQTQYS GMQQPAVYTA YSQTGQPYSL PTYDLGVMLP AIKTESGLSQ TQSPLQSGCL SYSPGFSTPQ PGQTPYSYQM PGSSFAPSST IYANNSVSNS TNFSGSQQDY PSYTAFGQNQ YAQYYSASTY GAYMTSNNTA DGTPSSTSTY QLQESLPGLT NQPGEFDTMQ SPSTPIKDLD ERTCRSSGSK SRGRGRKNNP SPPPDSDLER VFVWDLDETI IVFHSLLTGS YAQKYGKDPP MAVTLGLRME EMIFNLADTH LFFNDLEECD QVHIDDVSSD DNGQDLSTYS FATDGFHAAA SSANLCLPTG VRGGVDWMRK LAFRYRRVKE LYNTYKNNVG GLLGPAKRDA WLQLRAEIEG LTDSWLTNAL KSLSIISTRS NCINVLVTTT QLIPALAKVL LYSLGGAFPI ENIYSATKIG KESCFERIMQ RFGRKVVYVV IGDGVEEEQA AKKHNMPFWR ISSHSDLLAL HQALELEYL
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