About Keratin, type II cytoskeletal 75
Keratin, type II cytoskeletal 75 (KRT75) is a protein
from Homo sapiens identified by UniProt accession
O95678, 551 residues long.
MolForge cross-references it against 0 known binders and
108 disease associations.
Target properties
| Protein name | Keratin, type II cytoskeletal 75 |
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| UniProt accession | O95678 |
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| Gene | KRT75 |
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| Organism | Homo sapiens |
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| Length | 551 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (108)
Diseases linked to this target (Open Targets).
- loose anagen syndrome · score 0.38
- glioblastoma multiforme · score 0.19
- Pseudofolliculitis barbae · score 0.19
- head and neck squamous cell carcinoma · score 0.19
- prostate adenocarcinoma · score 0.18
- clear cell renal carcinoma · score 0.18
- breast adenocarcinoma · score 0.18
- esophageal cancer · score 0.14
- low grade glioma · score 0.11
- metabolite measurement · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95678-F1 | alphafold | PREDICTED | 67.34 | — |
Amino-acid sequence (551 residues)
MSRQSSITFQ SGSRRGFSTT SAITPAAGRS RFSSVSVARS AAGSGGLGRI SSAGASFGSR SLYNLGGAKR VSINGCGSSC RSGFGGRASN RFGVNSGFGY GGGVGGGFSG PSFPVCPPGG IQEVTVNQSL LTPLHLQIDP TIQRVRAEER EQIKTLNNKF ASFIDKVRFL EQQNKVLETK WALLQEQGSR TVRQNLEPLF DSYTSELRRQ LESITTERGR LEAELRNMQD VVEDFKVRYE DEINKRTAAE NEFVALKKDV DAAYMNKVEL EAKVKSLPEE INFIHSVFDA ELSQLQTQVG DTSVVLSMDN NRNLDLDSII AEVKAQYEDI ANRSRAEAES WYQTKYEELQ VTAGRHGDDL RNTKQEISEM NRMIQRLRAE IDSVKKQCSS LQTAIADAEQ RGELALKDAR AKLVDLEEAL QKAKQDMARL LREYQELMNI KLALDVEIAT YRKLLEGEEC RLSGEGVSPV NISVVTSTLS SGYGSGSSIG GGNLGLGGGS GYSFTTSGGH SLGAGLGGSG FSATSNRGLG GSGSSVKFVS TTSSSQKSYT H
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