Centrosomal protein 43 (CEP43)

About Centrosomal protein 43

Centrosomal protein 43 (CEP43) is a protein from Homo sapiens identified by UniProt accession O95684, 399 residues long. MolForge cross-references it against 0 known binders and 168 disease associations.

Target properties

Protein name	Centrosomal protein 43
UniProt accession	O95684
Gene	CEP43
Organism	Homo sapiens
Length	399 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (168)

Diseases linked to this target (Open Targets).

cancer · score 0.57
myelodysplastic syndrome · score 0.46
leukemia · score 0.46
acute lymphoblastic leukemia · score 0.46
chronic myelogenous leukemia · score 0.37
Crohn's disease · score 0.35
inflammatory bowel disease · score 0.32
Graves disease · score 0.26
lung carcinoma · score 0.20
keratinocyte carcinoma · score 0.20

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95684-F1	alphafold	PREDICTED	62.98	—

Amino-acid sequence (399 residues)

MAATAAAVVA EEDTELRDLL VQTLENSGVL NRIKAELRAA VFLALEEQEK VENKTPLVNE SLKKFLNTKD GRLVASLVAE FLQFFNLDFT LAVFQPETST LQGLEGRENL ARDLGIIEAE GTVGGPLLLE VIRRCQQKEK GPTTGEGALD LSDVHSPPKS PEGKTSAQTT PSKIPRYKGQ GKKKTSGQKA GDKKANDEAN QSDTSVSLSE PKSKSSLHLL SHETKIGSFL SNRTLDGKDK AGLCPDEDDM EGDSFFDDPI PKPEKTYGLR KEPRKQAGSL ASLSDAPPLK SGLSSLAGAP SLKDSESKRG NTVLKDLKLI SDKIGSLGLG TGEDDDYVDD FNSTSHRSEK SEISIGEEIE EDLSVEIDDI NTSDKLDDLT QDLTVSQLSD VADYLEDVA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards