Protein phosphatase 1 regulatory subunit 3D (PPP1R3D)

About Protein phosphatase 1 regulatory subunit 3D

Protein phosphatase 1 regulatory subunit 3D (PPP1R3D) is a protein from Homo sapiens identified by UniProt accession O95685, 299 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.

Target properties

Protein name	Protein phosphatase 1 regulatory subunit 3D
UniProt accession	O95685
Gene	PPP1R3D
Organism	Homo sapiens
Length	299 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (27)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.36
mathematical ability · score 0.13
metabolite measurement · score 0.13
self reported educational attainment · score 0.12
reticulocyte count · score 0.11
breast milk measurement · score 0.11
rheumatoid arthritis · score 0.08
lymphocyte count · score 0.07
adolescent idiopathic scoliosis · score 0.07
mean platelet volume · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95685-F1	alphafold	PREDICTED	70.03	—

Amino-acid sequence (299 residues)

MSRGPSSAVL PSALGSRKLG PRSLSCLSDL DGGVALEPRA CRPPGSPGRA PPPTPAPSGC DPRLRPIILR RARSLPSSPE RRQKAAGAPG AACRPGCSQK LRVRFADALG LELAQVKVFN AGDDPSVPLH VLSRLAINSD LCCSSQDLEF TLHCLVPDFP PPVEAADFGE RLQRQLVCLE RVTCSDLGIS GTVRVCNVAF EKQVAVRYTF SGWRSTHEAV ARWRGPAGPE GTEDVFTFGF PVPPFLLELG SRVHFAVRYQ VAGAEYWDNN DHRDYSLTCR NHALHMPRGE CEESWIHFI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards