About Amyloid-beta A4 precursor protein-binding family B member 3
Amyloid-beta A4 precursor protein-binding family B member 3 (APBB3) is a protein
from Homo sapiens identified by UniProt accession
O95704, 486 residues long.
MolForge cross-references it against 0 known binders and
35 disease associations.
Target properties
| Protein name | Amyloid-beta A4 precursor protein-binding family B member 3 |
|---|
| UniProt accession | O95704 |
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| Gene | APBB3 |
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| Organism | Homo sapiens |
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| Length | 486 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (35)
Diseases linked to this target (Open Targets).
- Alzheimer disease · score 0.26
- Parkinson disease · score 0.26
- multiple sclerosis · score 0.26
- lysosomal storage disease · score 0.26
- neurodegenerative disease · score 0.26
- white matter microstructure measurement · score 0.11
- blood protein measurement · score 0.11
- aspartate aminotransferase measurement · score 0.08
- body height · score 0.08
- soluble CD14 measurement · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95704-F1 | alphafold | PREDICTED | 64.46 | — |
Amino-acid sequence (486 residues)
MLGKDYMLAI ILVNCDDDLW GDHSLEVEAG LPPGWRKIHD AAGTYYWHVP SGSTQWQRPT WELGDAEDPG TGTEGIWGLR PPKGRSFSSL ESSLDRSNSL SWYGGESYIQ SMEPGAKCFA VRSLGWVEVP EEDLAPGKSS IAVNNCIQQL AQTRSRSQPP DGAWGEGQNM LMILKKDAMS LVNPLDHSLI HCQPLVHIRV WGVGSSKGRD RDFAFVASDK DSCMLKCHVF CCDVPAKAIA SALHGLCAQI LSERVEVSGD ASCCSPDPIS PEDLPRQVEL LDAVSQAAQK YEALYMGTLP VTKAMGMDVL NEAIGTLTAR GDRNAWVPTM LSVSDSLMTA HPIQAEASTE EEPLWQCPVR LVTFIGVGRD PHTFGLIADL GRQSFQCAAF WCQPHAGGLS EAVQAACMVQ YQKCLVASAA RGKAWGAQAR ARLRLKRTSS MDSPGGPLPL PLLKGGVGGA GATPRKRGVF SFLDAFRLKP SLLHMP
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