About Steroid hormone receptor ERR2
Steroid hormone receptor ERR2 (ESRRB) is a protein
from Homo sapiens identified by UniProt accession
O95718, 433 residues long.
MolForge cross-references it against 0 known binders and
196 disease associations.
Target properties
| Protein name | Steroid hormone receptor ERR2 |
|---|
| UniProt accession | O95718 |
|---|
| Gene | ESRRB |
|---|
| Organism | Homo sapiens |
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| Length | 433 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (196)
Diseases linked to this target (Open Targets).
- deafness · score 0.64
- hearing loss, autosomal recessive · score 0.61
- Rare genetic deafness · score 0.39
- nonsyndromic genetic hearing loss · score 0.37
- hearing loss · score 0.37
- protein measurement · score 0.33
- PHF-tau measurement · score 0.33
- metabolite measurement · score 0.31
- Hearing impairment · score 0.29
- neurodegenerative disease · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95718-F1 | alphafold | PREDICTED | 77.96 | — |
Amino-acid sequence (433 residues)
MSSDDRHLGS SCGSFIKTEP SSPSSGIDAL SHHSPSGSSD ASGGFGLALG THANGLDSPP MFAGAGLGGT PCRKSYEDCA SGIMEDSAIK CEYMLNAIPK RLCLVCGDIA SGYHYGVASC EACKAFFKRT IQGNIEYSCP ATNECEITKR RRKSCQACRF MKCLKVGMLK EGVRLDRVRG GRQKYKRRLD SESSPYLSLQ ISPPAKKPLT KIVSYLLVAE PDKLYAMPPP GMPEGDIKAL TTLCDLADRE LVVIIGWAKH IPGFSSLSLG DQMSLLQSAW MEILILGIVY RSLPYDDKLV YAEDYIMDEE HSRLAGLLEL YRAILQLVRR YKKLKVEKEE FVTLKALALA NSDSMYIEDL EAVQKLQDLL HEALQDYELS QRHEEPWRTG KLLLTLPLLR QTAAKAVQHF YSVKLQGKVP MHKLFLEMLE AKV
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