Cytotoxic and regulatory T-cell molecule (CRTAM)

About Cytotoxic and regulatory T-cell molecule

Cytotoxic and regulatory T-cell molecule (CRTAM) is a protein from Homo sapiens identified by UniProt accession O95727, 393 residues long. MolForge cross-references it against 0 known binders and 166 disease associations.

Target properties

Protein name	Cytotoxic and regulatory T-cell molecule
UniProt accession	O95727
Gene	CRTAM
Organism	Homo sapiens
Length	393 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (166)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.42
age at menarche · score 0.33
IGF-1 measurement · score 0.29
testosterone measurement · score 0.21
pancreatic adenocarcinoma · score 0.18
insulin like growth factor measurement · score 0.15
FEV/FVC ratio · score 0.14
hematocrit · score 0.11
C-reactive protein measurement · score 0.10
inflammatory biomarker measurement · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95727-F1	alphafold	PREDICTED	73.52	—

Amino-acid sequence (393 residues)

MWWRVLSLLA WFPLQEASLT NHTETITVEE GQTLTLKCVT SLRKNSSLQW LTPSGFTIFL NEYPALKNSK YQLLHHSANQ LSITVPNVTL QDEGVYKCLH YSDSVSTKEV KVIVLATPFK PILEASVIRK QNGEEHVVLM CSTMRSKPPP QITWLLGNSM EVSGGTLHEF ETDGKKCNTT STLIIHTYGK NSTVDCIIRH RGLQGRKLVA PFRFEDLVTD EETASDALER NSLSSQDPQQ PTSTVSVTED SSTSEIDKEE KEQTTQDPDL TTEANPQYLG LARKKSGILL LTLVSFLIFI LFIIVQLFIM KLRKAHVIWK KENEVSEHTL ESYRSRSNNE ETSSEEKNGQ SSHPMRCMNY ITKLYSEAKT KRKENVQHSK LEEKHIQVPE SIV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards