Geranylgeranyl pyrophosphate synthase (GGPS1)

About Geranylgeranyl pyrophosphate synthase

Geranylgeranyl pyrophosphate synthase (GGPS1) is a protein from Homo sapiens identified by UniProt accession O95749, 300 residues long. MolForge cross-references it against 0 known binders and 124 disease associations.

Target properties

Protein name	Geranylgeranyl pyrophosphate synthase
UniProt accession	O95749
Gene	GGPS1
Organism	Homo sapiens
Length	300 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (3)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (124)

Diseases linked to this target (Open Targets).

muscular dystrophy, congenital hearing loss, and ovarian insufficiency syndrome · score 0.68
multiple sclerosis · score 0.43
lysosomal storage disease · score 0.43
Alzheimer disease · score 0.43
neurodegenerative disease · score 0.43
Parkinson disease · score 0.43
Perrault syndrome 1 · score 0.37
Perrault syndrome 2 · score 0.37
lean body mass · score 0.26
body height · score 0.25

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95749-F1	alphafold	PREDICTED	94.57	—

Amino-acid sequence (300 residues)

MEKTQETVQR ILLEPYKYLL QLPGKQVRTK LSQAFNHWLK VPEDKLQIII EVTEMLHNAS LLIDDIEDNS KLRRGFPVAH SIYGIPSVIN SANYVYFLGL EKVLTLDHPD AVKLFTRQLL ELHQGQGLDI YWRDNYTCPT EEEYKAMVLQ KTGGLFGLAV GLMQLFSDYK EDLKPLLNTL GLFFQIRDDY ANLHSKEYSE NKSFCEDLTE GKFSFPTIHA IWSRPESTQV QNILRQRTEN IDIKKYCVHY LEDVGSFEYT RNTLKELEAK AYKQIDARGG NPELVALVKH LSKMFKEENE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards