About Fibroblast growth factor 19
Fibroblast growth factor 19 (FGF19) is a protein
from Homo sapiens identified by UniProt accession
O95750, 216 residues long.
MolForge cross-references it against 0 known binders and
418 disease associations.
Target properties
| Protein name | Fibroblast growth factor 19 |
|---|
| UniProt accession | O95750 |
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| Gene | FGF19 |
|---|
| Organism | Homo sapiens |
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| Length | 216 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (418)
Diseases linked to this target (Open Targets).
- cancer · score 0.40
- lung adenocarcinoma · score 0.30
- cutaneous melanoma · score 0.29
- head and neck squamous cell carcinoma · score 0.28
- hair colour measurement · score 0.22
- breast carcinoma · score 0.17
- sex hormone-binding globulin measurement · score 0.15
- gastric adenocarcinoma · score 0.14
- breast cancer · score 0.14
- HER2 Positive Breast Carcinoma · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95750-F1 | alphafold | PREDICTED | 79.83 | — |
Amino-acid sequence (216 residues)
MRSGCVVVHV WILAGLWLAV AGRPLAFSDA GPHVHYGWGD PIRLRHLYTS GPHGLSSCFL RIRADGVVDC ARGQSAHSLL EIKAVALRTV AIKGVHSVRY LCMGADGKMQ GLLQYSEEDC AFEEEIRPDG YNVYRSEKHR LPVSLSSAKQ RQLYKNRGFL PLSHFLPMLP MVPEEPEDLR GHLESDMFSS PLETDSMDPF GLVTGLEAVR SPSFEK
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